| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Paulson & Co John Paulson | 2,089,523 | $632,373,241 | -1% | 31.44% |
| 2. | Baker Bros. Advisors Julian Baker And Felix Baker | 1,976,018 | $598,022,088 | +1% | 5.8% |
| 3. | VenBio Select Advisor Kurt Von Emster | 1,875,000 | $567,450,000 | -8% | 9.94% |
| 4. | Adage Capital Management Phill Gross And Robert Atchinson | 376,163 | $113,841,970 | +97% | 0.19% |
| 5. | Hood River Capital Management David Swank | 244,738 | $74,067,508 | +1% | 1.03% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $392.24 | 9,362 | $3,672,178.03 | 1,947,968 | 2025-08-20 | Filing | |
| $392.24 | 862 | $338,113.38 | 202,813 | 2025-08-20 | Filing | |
| $389.89 | 2,506 | $977,058.83 | 1,938,606 | 2025-08-20 | Filing | |
| $389.89 | 231 | $90,064.08 | 201,951 | 2025-08-20 | Filing | |
| $389.00 | 366 | $142,374.00 | 1,936,100 | 2025-08-20 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $401.00 | 1,131 | $453,531.34 | 109,753 | 2025-08-21 | Filing | |
| $400.03 | 6,485 | $2,594,225.03 | 110,884 | 2025-08-21 | Filing | |
| $376.62 | 42 | $15,818.04 | 9,173 | 2025-08-18 | Filing | |
| $375.75 | 190 | $71,393.18 | 9,215 | 2025-08-18 | Filing | |
| $374.13 | 68 | $25,441.14 | 9,405 | 2025-08-18 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 2,191,753 | $663,279,292 | 0.33% | |
| 2. | 1,993,687 | $603,369,434 | 8.59% | |
| 3. | 1,877,281 | $568,140,321 | 0.01% | |
| 4. | 1,438,724 | $435,415,581 | 0.01% | |
| 5. | 690,715 | $209,037,988 | 0.01% |
