| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 14,356,589 | $30,005 | -1% | 1.2% |
| 2. | D E Shaw D. E. Shaw | 3,228,704 | $6,748 | +15% | 0% |
| 3. | Citadel Investment Group Ken Griffin | 451,812 | $945 | +1268% | 0% |
| 4. | Fisher Asset Management Ken Fisher | 368,194 | $770 | +116% | 0% |
| 5. | Millennium Management Israel Englander | 368,654 | $770 | +45% | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.20 | 10,937,500 | Large Shareholder, Director | 32,259,461 | 2020-12-16 | Filing | |
| $3.20 | 10,937,500 | Large Shareholder, Director | 32,259,461 | 2020-12-16 | Filing | |
| $3.10 | 50,000 | Officer, Director | 227,539 | 2019-09-18 | Filing | |
| $3.52 | 2,000 | Officer | 18,661 | 2019-09-18 | Filing | |
| $3.23 | 2,500 | Officer | 16,661 | 2019-09-18 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $6.93 | 12,000 | Officer | 71,766 | 2021-03-15 | Filing | |
| $6.90 | 10,912 | Officer | 71,766 | 2021-03-15 | Filing | |
| $12.91 | 10,000 | Officer | 25,643 | 2018-06-08 | Filing | |
| $15.00 | 1,500 | Officer | 15,946 | 2016-06-06 | Filing | |
| $13.00 | 6,000 | Officer | 15,946 | 2016-05-23 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 106,564 | $222,719 | 0% | |
| 2. | 83,874 | $175,297 | 0% | |
| 3. | 71,178,364 | $148,763 | 6.22% | |
| 4. | 10,000 | $20,900 | 0% | |
| 5. | 5,290,549 | $11,057 | 0% |
