| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 6,651,429 | $376,470,881 | 2.72% | |
| 2. | VenBio Select Advisor Kurt Von Emster | 6,350,000 | $359,410,000 | -4% | 4.65% |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 5,502,710 | $311,453,386 | 12.63% | |
| 4. | Siren L.L.C. Raymond Debbane | 3,428,150 | $194,033,290 | 7.59% | |
| 5. | Driehaus Capital Richard Driehaus | 939,094 | $53,152,720 | +1% | 0.38% |