| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 6,000,000 | $87,600 | -15% | 1.24% |
| 2. | Palo Alto Investors William Leland Edwards | 5,086,152 | $74,258 | +21% | 4.07% |
| 3. | 43,300,000 | $51,889 | 0.01% | ||
| 4. | Adage Capital Management Phill Gross And Robert Atchinson | 3,212,931 | $46,909 | -2% | 0.11% |
| 5. | 38,523,000 | $46,694 | +10% | 0.33% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $14.54 | 7,500 | Officer | 7,500 | 2020-08-26 | Filing | |
| $33.00 | 2,000 | Officer | 3,000 | 2015-04-07 | Filing | |
| $29.43 | 1,000 | Officer | 1,000 | 2015-04-06 | Filing | |
| $29.31 | 3,000 | Director | 3,000 | 2015-04-02 | Filing | |
| $29.71 | 5,000 | Officer | 5,000 | 2015-04-02 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $18.00 | 5,000 | Director | 0 | 2020-12-18 | Filing | |
| $16.14 | 5,000 | Director | 0 | 2020-12-07 | Filing | |
| $16.04 | 5,000 | Director | 5,000 | 2020-12-07 | Filing | |
| $16.05 | 5,000 | Director | 10,000 | 2020-12-07 | Filing | |
| $16.05 | 5,000 | Director | 15,000 | 2020-12-07 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 22,303 | $345,250 | 1.09% | |
| 2. | 29,429 | $456 | 0.09% | |
| 3. | 19,210 | $297 | 0.28% | |
| 4. | 12,410 | $192 | 0.02% | |
| 5. | 1,153 | $18 | 0% |
