| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 1,706,469 | $211,858,126 | 12.57% | |
| 2. | Renaissance Technologies Jim Simons | 1,044,574 | $129,683,862 | +5% | 0.2% |
| 3. | Polaris Capital Management Bernard Horn | 879,160 | $109,147,714 | -20% | 6.24% |
| 4. | Citadel Investment Group Ken Griffin | 696,944 | $86,525,598 | +38% | 0.02% |
| 5. | GMT Capital Thomas E. Claugus | 672,900 | $83,540,535 | +33% | 4.43% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $103.00 | 1,621 | $166,961.54 | 101,621 | 2025-05-12 | Filing | |
| $99.71 | 100 | $9,971.00 | 100,000 | 2025-05-09 | Filing | |
| $98.91 | 19,216 | $1,900,677.62 | 99,900 | 2025-05-09 | Filing | |
| $98.10 | 80,684 | $7,915,471.55 | 80,684 | 2025-05-09 | Filing | |
| $119.65 | 12,000 | $1,435,800.00 | 27,932 | 2024-03-01 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $110.00 | 500 | $55,000.00 | 437,973 | 2025-06-03 | Filing | |
| $107.90 | 500 | $53,950.00 | 438,473 | 2025-06-02 | Filing | |
| $120.00 | 500 | $60,000.00 | 438,807 | 2025-05-02 | Filing | |
| $116.35 | 1,000 | $116,350.00 | 439,307 | 2025-05-01 | Filing | |
| $123.75 | 1,500 | $185,625.00 | 440,307 | 2025-04-01 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 6,017,403 | $747,060,582 | 0.01% | |
| 2. | 5,765,331 | $715,765,783 | 0.02% | |
| 3. | 2,328,430 | $289,066,499 | 0.07% | |
| 4. | 1,966,590 | $244,152,149 | 0.01% | |
| 5. | 1,927,794 | $239,335,625 | 0.04% |
