| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | 127,800,000 | $118,341,522 | 2.44% | ||
| 2. | ARK Investment Management Catherine D. Wood | 2,673,538 | $100,979,530 | -28% | 0.87% |
| 3. | OrbiMed Advisors Samuel Isaly | 1,993,600 | $75,298,272 | +160% | 1.44% |
| 4. | 79,898,000 | $72,811,602 | +2% | 2.82% | |
| 5. | 52,740,000 | $48,949,313 | 1.64% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $40.79 | 1,815 | Officer | 31,941 | 2023-02-06 | Filing | |
| $40.67 | 1,413 | Officer | 24,946 | 2023-02-06 | Filing | |
| $40.86 | 1,920 | Officer | 41,581 | 2023-02-06 | Filing | |
| $40.69 | 24,651 | Officer, Director | 145,305 | 2023-02-06 | Filing | |
| $40.59 | 2,079 | Officer | 75,496 | 2023-02-06 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 21,307,519 | $804,784,993 | 0.07% | |
| 2. | 13,546,694 | $511,658,632 | 0.01% | |
| 3. | 9,743,900 | $368,027,103 | 4.88% | |
| 4. | 9,079,557 | $342,934,868 | 0.01% | |
| 5. | 5,425,642 | $204,926,506 | 0.2% |
