| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 2,017,250 | $122,548 | 11.03% | |
| 2. | Hillhouse Capital Management Lei Zhang | 2,686,196 | $163,186 | 4.32% | |
| 3. | Opaleye Management James A. Silverman | 200,000 | $12,150 | -45% | 3.09% |
| 4. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 17,138 | $1,041 | -7% | 2.48% |
| 5. | 350,000 | $21,263 | 1.91% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $46.70 | 3,500 | Director | 3,500 | 2017-12-04 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $39.24 | 1,000 | Director | 32,700 | 2018-11-15 | Filing | |
| $40.36 | 600 | Director | 23,700 | 2018-11-15 | Filing | |
| $39.67 | 3,400 | Director | 24,300 | 2018-11-15 | Filing | |
| $44.61 | 918 | Officer, Director | 91,122 | 2018-11-02 | Filing | |
| $45.18 | 1,100 | Officer, Director | 2,665,769 | 2018-11-02 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 130,646 | $7,937 | 3.75% | |
| 2. | 251,190 | $15,260 | 1.52% | |
| 3. | 71,400 | $4,338 | 0.88% | |
| 4. | 316,384 | $19,220 | 0.7% | |
| 5. | 15,050 | $914 | 0.61% |
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