| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 2,017,250 | $122,548 | 11.03% | |
| 2. | Hillhouse Capital Management Lei Zhang | 2,686,196 | $163,186 | 4.32% | |
| 3. | Opaleye Management James A. Silverman | 200,000 | $12,150 | -45% | 3.09% |
| 4. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 17,138 | $1,041 | -7% | 2.48% |
| 5. | 350,000 | $21,263 | 1.91% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $46.70 | 3,500 | Director | 3,500 | 2017-12-04 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $45.90 | 2,000 | Director | 27,700 | 2019-01-07 | Filing | |
| $45.05 | 25,600 | Officer, Director | 2,613,697 | 2019-01-04 | Filing | |
| $44.12 | 4,400 | Officer, Director | 2,639,297 | 2019-01-04 | Filing | |
| $45.75 | 100 | Officer, Director | 2,622,785 | 2019-01-03 | Filing | |
| $44.84 | 6,507 | Officer, Director | 2,622,885 | 2019-01-03 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 6,000 | $269 | 0.05% | |
| 2. | 6,174 | $286 | 0% | |
| 3. | 614 | $28 | 0% | |
| 4. | 0 | $0 | 0% | |
| 5. | 336 | $1,555 | 0% |
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