| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 2,017,250 | $126,280 | +1% | 12.02% |
| 2. | Opaleye Management James A. Silverman | 360,000 | $22,536 | 5.83% | |
| 3. | Hillhouse Capital Management Lei Zhang | 2,686,196 | $168,156 | +4% | 2.86% |
| 4. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 18,423 | $1,153 | +1% | 2.5% |
| 5. | 350,000 | $21,910 | +8% | 2.08% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $46.70 | 3,500 | Director | 3,500 | 2017-12-04 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $59.50 | 2,318 | Officer | 228,604 | 2018-09-13 | Filing | |
| $57.35 | 1,011 | Officer | 220,422 | 2018-09-10 | Filing | |
| $57.60 | 1,700 | Director | 131,540 | 2018-09-10 | Filing | |
| $57.19 | 4,300 | Director | 133,240 | 2018-09-10 | Filing | |
| $57.30 | 200 | Officer, Director | 98,466 | 2018-09-07 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 130,646 | $8,178 | 6.03% | |
| 2. | 50,880 | $3,185 | 1.72% | |
| 3. | 239,547 | $14,996 | 1.53% | |
| 4. | 2,405 | $151 | 1.22% | |
| 5. | 71,400 | $4,470 | 0.98% |
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