| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 2,047,737 | $97,063 | +18% | 10.92% |
| 2. | Opaleye Management James A. Silverman | 360,000 | $17,064 | 5.46% | |
| 3. | Hillhouse Capital Management Lei Zhang | 2,386,196 | $113,106 | -5% | 1.92% |
| 4. | Nexthera Capital Ori Hershkovitz | 200,841 | $9,520 | -8% | 1.75% |
| 5. | 285,400 | $13,528 | 1.52% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $46.70 | 3,500 | Director | 3,500 | 2017-12-04 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $47.70 | 1,000 | Director | 29,000 | 2018-04-19 | Filing | |
| $47.69 | 4,000 | Director | 20,000 | 2018-04-19 | Filing | |
| $48.60 | 918 | Officer, Director | 114,990 | 2018-04-18 | Filing | |
| $49.22 | 800 | Officer, Director | 2,906,173 | 2018-04-18 | Filing | |
| $48.68 | 18,100 | Officer, Director | 2,906,973 | 2018-04-18 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 169,547 | $7,833 | 0.96% | |
| 2. | 31,072 | $1,436 | 0.85% | |
| 3. | 28,415 | $1,313 | 0.24% | |
| 4. | 6,674 | $308 | 0.07% | |
| 5. | 10,237 | $472 | 0.07% |
