| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 1,511,785 | $68,302 | +798% | 6.9% |
| 2. | Opaleye Management James A. Silverman | 150,000 | $6,777 | -25% | 2.06% |
| 3. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 302,660 | $13,674 | +273% | 1.63% |
| 4. | 277,500 | $12,537 | 1.26% | ||
| 5. | Farallon Capital Thomas Steyer | 1,700,000 | $76,806 | +86% | 0.63% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $46.70 | 3,500 | Director | 3,500 | 2017-12-04 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $41.67 | 420 | Director | 28,400 | 2019-09-09 | Filing | |
| $40.90 | 5,580 | Director | 28,820 | 2019-09-09 | Filing | |
| $43.68 | 584 | Officer | 151,570 | 2019-08-23 | Filing | |
| $42.94 | 1,816 | Officer | 152,154 | 2019-08-23 | Filing | |
| $42.05 | 3,225 | Officer | 153,970 | 2019-08-23 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 156,730 | $7,081 | 4.87% | |
| 2. | 2,724,519 | $123,094 | 2.75% | |
| 3. | 347,439 | $15,697 | 1.72% | |
| 4. | 130,646 | $5,903 | 1.5% | |
| 5. | 36,471 | $1,648 | 1.37% |
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