| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 1,293,807 | $47,845 | -15% | 6.04% |
| 2. | 652,500 | $24,130 | +136% | 3.04% | |
| 3. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 333,460 | $12,331 | +11% | 2.12% |
| 4. | Opaleye Management James A. Silverman | 150,000 | $5,547 | 2% | |
| 5. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 306,000 | $11,316 | 0.45% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $46.70 | 3,500 | Director | 3,500 | 2017-12-04 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $35.18 | 2,025 | Officer | 139,628 | 2019-11-14 | Filing | |
| $34.50 | 3,600 | Officer | 141,653 | 2019-11-14 | Filing | |
| $34.54 | 5,625 | Officer | 139,628 | 2019-11-13 | Filing | |
| $38.85 | 1,486 | Director | 28,400 | 2019-11-07 | Filing | |
| $38.08 | 4,514 | Director | 29,886 | 2019-11-07 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 130,646 | $4,831 | 1.49% | |
| 2. | 25,260 | $934 | 0.81% | |
| 3. | 71,400 | $2,640 | 0.58% | |
| 4. | 26,750 | $989 | 0.57% | |
| 5. | 233,142 | $8,622 | 0.37% |
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