| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Redmile Group Jeremy Green | 11,216,809 | $219,513 | 5.25% | |
| 2. | Casdin Capital Eli Casdin | 2,550,000 | $49,904 | 4.58% | |
| 3. | Copernicus Capital Management John W. Rende | 161,977 | $3,170 | +116% | 4.15% |
| 4. | DAFNA Capital Management Nathan Fischel | 470,000 | $9,198 | 3.15% | |
| 5. | Eversept Partners Kamran Moghtaderi | 360,656 | $7,058 | +157% | 1.36% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.50 | 857,143 | Large Shareholder, Director | 11,216,809 | 2019-09-16 | Filing | |
| $13.50 | 3,703,704 | Large Shareholder, Director | 10,359,666 | 2018-09-25 | Filing | |
| $2.66 | 37,593 | Officer | 37,593 | 2016-11-23 | Filing | |
| $2.66 | 375,939 | Director | 459,272 | 2016-11-23 | Filing | |
| $2.66 | 56,390 | Director | 56,390 | 2016-11-23 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $25.45 | 25,000 | Officer, Director | 419,969 | 2020-01-30 | Filing | |
| $20.69 | 5,700 | Officer | 86,058 | 2020-01-08 | Filing | |
| $20.72 | 5,700 | Officer | 99,518 | 2020-01-08 | Filing | |
| $20.70 | 5,700 | Officer | 143,091 | 2020-01-08 | Filing | |
| $20.34 | 100 | Officer | 123,791 | 2019-12-30 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,139,783 | $22,306 | 16.22% | |
| 2. | 2,285,714 | $44,731 | 7.45% | |
| 3. | 2,000,000 | $39,140 | 1.51% | |
| 4. | 635,143 | $12,430 | 0.89% | |
| 5. | 24,200 | $474 | 0.37% |
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