| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Sphera Global Healthcare Fund Doron Breen And Mori Arkin | 508,322 | $3,614 | 0.27% | |
| 2. | Ikarian Capital Neil Shahrestani | 300,000 | $2,133 | -24% | 0.07% |
| 3. | Citadel Investment Group Ken Griffin | 293,867 | $2,090 | 0% | |
| 4. | Tri Locum Partners Prashanth Jayaram | 293,419 | $2,086 | 0.51% | |
| 5. | Pura Vida Investments Efrem Kamen | 273,958 | $1,948 | -43% | 0.05% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $2.00 | 850,000 | Large Shareholder | 2,167,261 | 2017-07-19 | Filing | |
| $4.34 | 134,200 | Large Shareholder | 559,900 | 2017-02-23 | Filing | |
| $3.00 | 3,100 | Director | 3,100 | 2014-11-20 | Filing | |
| $3.00 | 100,000 | Officer, Director | 241,416 | 2013-05-21 | Filing | |
| $3.00 | 100,000 | Officer, Director | 268,292 | 2013-05-21 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $0.51 | 650,000 | Large Shareholder | 2,806,900 | 2011-09-23 | Filing | |
| $0.60 | 500,000 | Large Shareholder | 3,456,900 | 2011-09-22 | Filing | |
| $1.80 | 50,000 | Large Shareholder | 3,956,900 | 2011-05-13 | Filing | |
| $1.73 | 100,000 | Large Shareholder | 4,006,900 | 2011-05-13 | Filing | |
| $1.90 | 142,000 | Large Shareholder | 4,106,900 | 2010-11-30 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 380,000 | $2,702 | 0.91% | |
| 2. | 357,524 | $2,542 | 0.08% | |
| 3. | 299,969 | $2,132 | 0% | |
| 4. | 250,000 | $1,787 | 0.08% | |
| 5. | 116,674 | $830 | 0% |
