| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 2,020,000 | $5,191 | +71% | 1.93% |
| 2. | Redmile Group Jeremy Green | 3,564,950 | $9,162 | -1% | 0.36% |
| 3. | Aisling Capital Dennis Purcell | 472,943 | $1,215 | 0.34% | |
| 4. | 683 Capital Partners Ari Zweiman | 300,000 | $771 | 0.04% | |
| 5. | Point72 Asset Management Steve Cohen | 1,000,000 | $2,570 | 0.01% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $4.50 | 10,000 | Officer, Director | 99,685 | 2018-06-12 | Filing | |
| $4.47 | 22,417 | Officer, Director | 281,238 | 2016-08-29 | Filing | |
| $3.70 | 50,000 | Director | 381,440 | 2016-06-24 | Filing | |
| $3.69 | 13,188 | Officer, Director | 258,821 | 2016-06-24 | Filing | |
| $4.53 | 10,000 | Director | 331,440 | 2016-05-13 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $4.81 | 15,000 | Director | 108,167 | 2018-05-18 | Filing | |
| $4.80 | 30,000 | Director | 123,167 | 2018-05-17 | Filing | |
| $4.79 | 30,000 | Director | 153,167 | 2018-05-16 | Filing | |
| $4.69 | 30,000 | Director | 183,167 | 2018-05-15 | Filing | |
| $4.67 | 22,553 | Director | 213,167 | 2018-05-14 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,350,000 | $3,470 | 0.95% | |
| 2. | 474,578 | $1,220 | 0.15% | |
| 3. | 4,717,953 | $12,125 | 0.12% | |
| 4. | 1,000,000 | $2,570 | 0.09% | |
| 5. | 25,491 | $66 | 0.06% |
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