| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | 341,400 | $29,070 | +14% | 11.98% | |
| 2. | Palo Alto Investors William Leland Edwards | 2,559,733 | $217,961 | +1% | 11.6% |
| 3. | VenBio Select Advisor Kurt Von Emster | 1,360,000 | $115,804 | -1% | 6.92% |
| 4. | Highline Capital Management Jacob Doft | 1,013,119 | $86,267 | -22% | 5.78% |
| 5. | Baker Bros. Advisors Julian Baker And Felix Baker | 7,589,294 | $646,228 | +1% | 5.29% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $21.76 | 161 | Officer | 100,574 | 2012-10-31 | Filing | |
| $21.76 | 548 | Officer | 15,294 | 2012-10-31 | Filing | |
| $27.91 | 588 | Officer | 23,245 | 2012-10-31 | Filing | |
| $13.26 | 333 | Officer | 83,493 | 2011-10-31 | Filing | |
| $13.23 | 201 | Officer | 46,679 | 2011-10-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $95.20 | 4,000 | Officer, Director | 288,290 | 2019-02-14 | Filing | |
| $98.63 | 4,000 | Officer, Director | 288,290 | 2019-02-05 | Filing | |
| $96.82 | 3,000 | Officer, Director | 288,290 | 2019-01-22 | Filing | |
| $93.79 | 4,000 | Officer, Director | 288,290 | 2019-01-14 | Filing | |
| $90.55 | 3,000 | Officer, Director | 288,290 | 2019-01-10 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 26,902,000 | $26,819 | 3.92% | |
| 2. | 92,284 | $6,175 | 3.83% | |
| 3. | 224,639 | $19,128 | 2.26% | |
| 4. | 6,107,460 | $520,050 | 1.85% | |
| 5. | 176,549 | $15,033 | 1.71% |
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