| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Palo Alto Investors William Leland Edwards | 2,497,806 | $222,729 | +3% | 9.59% |
| 2. | VenBio Select Advisor Kurt Von Emster | 1,189,524 | $106,070 | +99% | 6.87% |
| 3. | Baker Bros. Advisors Julian Baker And Felix Baker | 7,583,084 | $676,184 | +29% | 5.86% |
| 4. | Pura Vida Investments Efrem Kamen | 43,700 | $3,896,729 | 2.88% | |
| 5. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 258,503 | $23,051 | +9% | 2.88% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $21.76 | 161 | Officer | 100,574 | 2012-10-31 | Filing | |
| $21.76 | 548 | Officer | 15,294 | 2012-10-31 | Filing | |
| $27.91 | 588 | Officer | 23,245 | 2012-10-31 | Filing | |
| $13.26 | 333 | Officer | 83,493 | 2011-10-31 | Filing | |
| $13.23 | 201 | Officer | 46,679 | 2011-10-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $85.00 | 3,750 | Director | 14,860 | 2018-04-17 | Filing | |
| $80.12 | 2,119 | Officer | 52,914 | 2018-04-02 | Filing | |
| $80.12 | 6,650 | Officer | 156,676 | 2018-04-02 | Filing | |
| $80.12 | 3,350 | Officer | 156,676 | 2018-04-02 | Filing | |
| $79.69 | 1,537 | Officer | 55,033 | 2018-03-29 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 204,849 | $16,607 | 2.04% | |
| 2. | 34,721 | $2,815 | 1.25% | |
| 3. | 7,100,000 | $6,681,214 | 1.06% | |
| 4. | 11,762,823 | $953,612 | 0.94% | |
| 5. | 5,115,000 | $5,649,620 | 0.89% |
