| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Polar Capital Brian Ashford-Russell And Tim Woolley | 23,500,000 | $2,389,081 | +43% | 14.38% |
| 2. | Palo Alto Investors William Leland Edwards | 2,549,431 | $240,156 | +1% | 9.59% |
| 3. | 16,643,000 | $17,743 | +32% | 8.55% | |
| 4. | VenBio Select Advisor Kurt Von Emster | 1,622,770 | $152,865 | -6% | 5.88% |
| 5. | Baker Bros. Advisors Julian Baker And Felix Baker | 7,583,084 | $714,327 | 5.36% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $21.76 | 161 | Officer | 100,574 | 2012-10-31 | Filing | |
| $21.76 | 548 | Officer | 15,294 | 2012-10-31 | Filing | |
| $27.91 | 588 | Officer | 23,245 | 2012-10-31 | Filing | |
| $13.26 | 333 | Officer | 83,493 | 2011-10-31 | Filing | |
| $13.23 | 201 | Officer | 46,679 | 2011-10-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $105.00 | 5,173 | Officer | 71,882 | 2018-08-07 | Filing | |
| $104.50 | 2,500 | Officer | 12,375 | 2018-08-07 | Filing | |
| $101.69 | 1,500 | Officer, Director | 285,290 | 2018-07-23 | Filing | |
| $93.52 | 2,150 | Director | 19,160 | 2018-06-27 | Filing | |
| $99.01 | 472 | Officer | 51,070 | 2018-06-22 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 5,000,000 | $5,323 | 4.14% | |
| 2. | 57,900 | $5,454 | 3.99% | |
| 3. | 84,257 | $7,937 | 3.78% | |
| 4. | 97,284 | $9,164 | 3.51% | |
| 5. | 241,695 | $22,768 | 2.37% |
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