| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Polar Capital Brian Ashford-Russell And Tim Woolley | 23,500,000 | $2,389,081 | +43% | 14.38% |
| 2. | Palo Alto Investors William Leland Edwards | 2,549,431 | $240,156 | +1% | 9.59% |
| 3. | 16,643,000 | $17,743 | +32% | 8.55% | |
| 4. | VenBio Select Advisor Kurt Von Emster | 1,622,770 | $152,865 | -6% | 5.88% |
| 5. | Baker Bros. Advisors Julian Baker And Felix Baker | 7,583,084 | $714,327 | 5.36% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $21.76 | 161 | Officer | 100,574 | 2012-10-31 | Filing | |
| $21.76 | 548 | Officer | 15,294 | 2012-10-31 | Filing | |
| $27.91 | 588 | Officer | 23,245 | 2012-10-31 | Filing | |
| $13.26 | 333 | Officer | 83,493 | 2011-10-31 | Filing | |
| $13.23 | 201 | Officer | 46,679 | 2011-10-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $98.98 | 1,000 | Officer | 49,135 | 2018-10-03 | Filing | |
| $99.36 | 1,500 | Officer, Director | 286,290 | 2018-10-03 | Filing | |
| $97.93 | 2,150 | Director | 19,160 | 2018-09-27 | Filing | |
| $99.46 | 616 | Officer | 72,734 | 2018-09-14 | Filing | |
| $99.46 | 200 | Officer | 73,350 | 2018-09-14 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 264,849 | $25,682 | 2.57% | |
| 2. | 1,404,528 | $136,195 | 1.33% | |
| 3. | 35,479 | $3,440 | 0.98% | |
| 4. | 5,500 | $533 | 0.34% | |
| 5. | 14,677 | $1,382 | 0.32% |
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