| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Palo Alto Investors William Leland Edwards | 2,606,485 | $223,245 | -2% | 10.85% |
| 2. | VenBio Select Advisor Kurt Von Emster | 2,115,000 | $181,150 | +89% | 6.26% |
| 3. | York Capital Management James Dinan | 1,116,727 | $95,648 | 3.87% | |
| 4. | Highline Capital Management Jacob Doft | 607,021 | $51,991 | -44% | 3.8% |
| 5. | Partner Fund Management Christopher Medlock James | 2,079,388 | $178,100 | 3.38% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $21.76 | 161 | Officer | 100,574 | 2012-10-31 | Filing | |
| $21.76 | 548 | Officer | 15,294 | 2012-10-31 | Filing | |
| $27.91 | 588 | Officer | 23,245 | 2012-10-31 | Filing | |
| $13.26 | 333 | Officer | 83,493 | 2011-10-31 | Filing | |
| $13.23 | 201 | Officer | 46,679 | 2011-10-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $81.08 | 3,750 | Director | 23,590 | 2019-06-17 | Filing | |
| $82.52 | 10,000 | Officer, Director | 326,520 | 2019-05-10 | Filing | |
| $81.97 | 4,000 | Officer, Director | 326,520 | 2019-05-09 | Filing | |
| $82.16 | 4,000 | Officer, Director | 326,520 | 2019-05-08 | Filing | |
| $84.41 | 200 | Officer, Director | 326,211 | 2019-04-26 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 176,325 | $15,102 | 8.17% | |
| 2. | 19,000,000 | $19,742 | 4.12% | |
| 3. | 25,929,000 | $27,077 | 3.07% | |
| 4. | 30,715,000 | $32,001 | 2.82% | |
| 5. | 281,349 | $24,098 | 2.65% |
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