| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 7,589,294 | $665,505 | 2.5% | |
| 2. | Citadel Investment Group Ken Griffin | 2,995,270 | $262,655 | +21% | 0.07% |
| 3. | Palo Alto Investors William Leland Edwards | 2,155,050 | $188,976 | +25% | 9.9% |
| 4. | VenBio Select Advisor Kurt Von Emster | 1,650,000 | $144,689 | -6% | 2.49% |
| 5. | D E Shaw D. E. Shaw | 588,561 | $51,611 | +860% | 0.04% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $78.84 | 900 | Director | 30,740 | 2020-08-31 | Filing | |
| $78.22 | 11,900 | Director | 29,840 | 2020-08-31 | Filing | |
| $21.76 | 161 | Officer | 100,574 | 2012-10-31 | Filing | |
| $21.76 | 548 | Officer | 15,294 | 2012-10-31 | Filing | |
| $27.91 | 588 | Officer | 23,245 | 2012-10-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $83.58 | 7,000 | Officer, Director | 295,552 | 2021-02-19 | Filing | |
| $85.08 | 7,000 | Officer, Director | 295,552 | 2021-02-18 | Filing | |
| $84.54 | 8,000 | Officer, Director | 295,552 | 2021-02-17 | Filing | |
| $87.41 | 7,500 | Director | 18,850 | 2021-02-16 | Filing | |
| $82.67 | 8,334 | Officer, Director | 295,552 | 2021-01-29 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 2,017,564 | $153,496,269 | 0.08% | |
| 2. | 147,217 | $12,909,459 | 0.02% | |
| 3. | 58,447 | $5,125,217 | 0.04% | |
| 4. | 524 | $4,594,956 | 0.01% | |
| 5. | 28,600 | $2,507,934 | 0.02% |
