| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Palo Alto Investors William Leland Edwards | 2,545,482 | $206,362 | +2% | 8.82% |
| 2. | 12,643,000 | $13,010 | 6.8% | ||
| 3. | VenBio Select Advisor Kurt Von Emster | 1,710,995 | $138,710 | +44% | 6.62% |
| 4. | Baker Bros. Advisors Julian Baker And Felix Baker | 7,583,084 | $614,761 | 5.21% | |
| 5. | TAM Capital Management Tsachy Mishal | 52,180 | $4,230 | 3.99% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $21.76 | 161 | Officer | 100,574 | 2012-10-31 | Filing | |
| $21.76 | 548 | Officer | 15,294 | 2012-10-31 | Filing | |
| $27.91 | 588 | Officer | 23,245 | 2012-10-31 | Filing | |
| $13.26 | 333 | Officer | 83,493 | 2011-10-31 | Filing | |
| $13.23 | 201 | Officer | 46,679 | 2011-10-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $90.31 | 1,436 | Officer | 50,135 | 2018-06-11 | Filing | |
| $88.66 | 18,750 | Officer, Director | 290,600 | 2018-05-17 | Filing | |
| $89.13 | 18,750 | Officer, Director | 290,600 | 2018-05-16 | Filing | |
| $88.29 | 18,750 | Officer, Director | 290,600 | 2018-05-15 | Filing | |
| $89.22 | 18,750 | Officer, Director | 290,600 | 2018-05-14 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 5,000,000 | $5,134 | 3.57% | |
| 2. | 133,067 | $10,787,742 | 3.23% | |
| 3. | 63,400 | $5,140 | 3.22% | |
| 4. | 126,869 | $10,285 | 2.47% | |
| 5. | 249,996 | $20,267 | 2.1% |
