| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Palo Alto Investors William Leland Edwards | 2,549,431 | $247,218 | 9.99% | |
| 2. | VenBio Select Advisor Kurt Von Emster | 1,368,103 | $132,665 | -16% | 6.09% |
| 3. | Highline Capital Management Jacob Doft | 1,286,950 | $124,796 | -3% | 5.77% |
| 4. | 300,000 | $29,091 | 5.57% | ||
| 5. | Prosight Capital Lawrence Hawkins | 96,428 | $9,351 | +67% | 5.21% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $21.76 | 161 | Officer | 100,574 | 2012-10-31 | Filing | |
| $21.76 | 548 | Officer | 15,294 | 2012-10-31 | Filing | |
| $27.91 | 588 | Officer | 23,245 | 2012-10-31 | Filing | |
| $13.26 | 333 | Officer | 83,493 | 2011-10-31 | Filing | |
| $13.23 | 201 | Officer | 46,679 | 2011-10-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $94.35 | 600 | Officer | 49,135 | 2018-11-14 | Filing | |
| $93.81 | 799 | Officer | 49,735 | 2018-11-14 | Filing | |
| $92.21 | 2,400 | Officer | 50,534 | 2018-11-14 | Filing | |
| $91.62 | 5,201 | Officer | 52,934 | 2018-11-14 | Filing | |
| $97.88 | 1,500 | Officer, Director | 288,290 | 2018-11-02 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 6,000,000 | $6,271 | 4.59% | |
| 2. | 97,284 | $7,234 | 3.43% | |
| 3. | 25,130,000 | $26,845 | 3.25% | |
| 4. | 33,935,000 | $35,929 | 3.11% | |
| 5. | 16,823 | $1,631 | 2.75% |
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