| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,690,221 | $176,442,170 | 6.3% | |
| 2. | Deep Track Capital David Kroin | 801,371 | $83,655,119 | 2.68% | |
| 3. | GLG Partners Noam Gottesman | 525,069 | $54,811,953 | +3% | 0.1% |
| 4. | Partner Fund Management Christopher Medlock James | 483,105 | $50,431,331 | -14% | 4.29% |
| 5. | Adage Capital Management Phill Gross And Robert Atchinson | 447,000 | $46,662,330 | +832% | 0.08% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $37.30 | 3,950 | $147,350.01 | 120,756 | 2021-11-19 | Filing | |
| $35.20 | 142 | $4,998.40 | 142 | 2021-11-18 | Filing | |
| $34.30 | 145 | $4,973.50 | 145 | 2021-11-18 | Filing | |
| $35.43 | 141 | $4,995.63 | 201 | 2021-11-18 | Filing | |
| $35.50 | 527 | $18,708.50 | 41,789 | 2021-11-18 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $100.12 | 6,014 | $602,121.68 | 0 | 2025-06-23 | Filing | |
| $102.47 | 7,500 | $768,525.00 | 0 | 2025-06-20 | Filing | |
| $100.90 | 7,500 | $756,750.00 | 0 | 2025-06-18 | Filing | |
| $100.26 | 7,500 | $751,950.00 | 0 | 2025-06-17 | Filing | |
| $102.42 | 7,500 | $768,150.00 | 0 | 2025-06-16 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 3,945,020 | $411,820,637 | 0.01% | |
| 2. | 3,834,990 | $400,334,606 | 0.01% | |
| 3. | 1,516,903 | $158,349,504 | 2.26% | |
| 4. | 1,137,748 | $118,770,000 | 0.15% | |
| 5. | 989,453 | $103,302,818 | 0.01% |
