| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 1,100,000 | $23,166 | -16% | 6.41% |
| 2. | Pura Vida Investments Efrem Kamen | 322,500 | $6,792 | 2.24% | |
| 3. | Deerfield Management James E. Flynn | 1,767,006 | $37,213 | +1589% | 1.42% |
| 4. | Archon Capital Management Constantinos J. Christofilis | 127,964 | $2,695 | 0.73% | |
| 5. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 603,970 | $12,720 | 0.49% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.25 | 5,000 | Director | 23,333 | 2019-06-13 | Filing | |
| $36.89 | 5,000 | Director | 18,333 | 2018-08-14 | Filing | |
| $7.50 | 13,333 | Director | 13,333 | 2016-10-07 | Filing | |
| $7.50 | 2,000 | Officer | 2,000 | 2016-10-07 | Filing | |
| $7.50 | 3,333 | Officer | 3,333 | 2016-10-07 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.00 | 20,000 | Officer | 18,974 | 2019-06-13 | Filing | |
| $22.63 | 20,000 | Officer | 25,588 | 2019-05-13 | Filing | |
| $33.00 | 45,000 | Officer, Director | 95,865 | 2018-11-30 | Filing | |
| $32.25 | 20,000 | Officer, Director | 140,865 | 2018-11-15 | Filing | |
| $32.93 | 12,000 | Officer, Director | 382,970 | 2018-11-14 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 191,128 | $3,784 | 0.15% | |
| 2. | 13,570 | $269 | 0.01% | |
| 3. | 5,607 | $111 | 0.01% | |
| 4. | 0 | $0 | 0% | |
| 5. | 46 | $1 | 0% |
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