| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Frazier Healthcare Partners Alan Frazier | 10,542,790 | $318,814 | 27.99% | |
| 2. | OrbiMed Advisors Samuel Isaly | 4,673,850 | $141,337 | 1.98% | |
| 3. | Vivo Capital Albert Cha And Frank Kung | 1,289,360 | $38,990 | -24% | 2.79% |
| 4. | RA Capital Management Peter Kolchinsky | 1,165,184 | $35,235 | 0.68% | |
| 5. | Polar Capital Brian Ashford-Russell And Tim Woolley | 450,000 | $13,608 | +20% | 0.11% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $25.00 | 296,000 | Large Shareholder, Director | 902,286 | 2020-10-02 | Filing | |
| $25.00 | 200,000 | Large Shareholder, Director | 4,267,564 | 2020-10-02 | Filing | |
| $25.00 | 296,000 | Large Shareholder, Director | 902,286 | 2020-10-02 | Filing | |
| $25.00 | 200,000 | Large Shareholder, Director | 4,267,564 | 2020-10-02 | Filing | |
| $17.00 | 294,117 | Large Shareholder | 3,979,292 | 2020-02-04 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $25.18 | 390 | Director | 177,400 | 2020-10-01 | Filing | |
| $28.18 | 1,810 | Director | 177,400 | 2020-10-01 | Filing | |
| $24.38 | 1,172 | Director | 176,178 | 2020-09-01 | Filing | |
| $24.38 | 1,028 | Director | 176,178 | 2020-09-01 | Filing | |
| $30.00 | 3,000 | Officer, Director | 566,928 | 2020-09-29 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 5,723,182 | $173,069 | 0.01% | |
| 2. | 3,979,292 | $120,334 | 12.6% | |
| 3. | 1,566,574 | $47,372 | 0% | |
| 4. | 1,066,540 | $32,252 | 0% | |
| 5. | 844,680 | $25,543 | 6.98% |
