| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Aisling Capital Dennis Purcell | 1,990,000 | $44,477 | 66.83% | |
| 2. | Palo Alto Investors William Leland Edwards | 3,748,939 | $83,789 | +171% | 3.49% |
| 3. | Opaleye Management James A. Silverman | 165,000 | $3,688 | +10% | 1.02% |
| 4. | Southpoint Capital Advisors John Smith Clark | 800,000 | $17,880 | 0.75% | |
| 5. | Dorset Management David M. Knott | 55,056 | $1,231 | +5% | 0.49% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $27.56 | 50 | Officer, Director | 63,650 | 2018-11-19 | Filing | |
| $27.56 | 3,600 | Officer, Director | 63,600 | 2018-11-19 | Filing | |
| $30.41 | 1,600 | Officer | 19,485 | 2018-06-13 | Filing | |
| $32.00 | 9,375 | Large Shareholder | 16,651 | 2018-02-22 | Filing | |
| $32.00 | 15,593 | Large Shareholder, Director | 22,869 | 2018-02-22 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $30.04 | 40,000 | Officer | 9,375 | 2018-11-19 | Filing | |
| $30.83 | 29,457 | Officer, Director | 315,308 | 2018-06-11 | Filing | |
| $30.70 | 42,106 | Officer, Director | 315,308 | 2018-06-08 | Filing | |
| $31.58 | 500 | Officer, Director | 315,308 | 2018-06-07 | Filing | |
| $30.95 | 32,098 | Officer, Director | 315,808 | 2018-06-07 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 2,726,568 | $60,939 | 27.51% | |
| 2. | 217,730 | $4,866 | 5.05% | |
| 3. | 647,254 | $14,466 | 3.76% | |
| 4. | 1,962,000 | $43,851 | 1.5% | |
| 5. | 852,991 | $19,064 | 0.77% |
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