| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 2,606,060 | $1,269,802,735 | +29% | 12.48% |
| 2. | Renaissance Technologies Jim Simons | 1,909,259 | $930,286,448 | -13% | 1.44% |
| 3. | AQR Capital Management Cliff Asness | 1,281,699 | $624,507,810 | +30% | 0.33% |
| 4. | Deerfield Management James E. Flynn | 425,993 | $207,565,089 | 2.65% | |
| 5. | D E Shaw D. E. Shaw | 306,971 | $149,571,620 | +375% | 0.08% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $82.83 | 4 | $331.32 | 1,684 | 2019-06-10 | Filing | |
| $114.06 | 6 | $684.36 | 1,686 | 2018-04-20 | Filing | |
| $126.20 | 5 | $631.00 | 1,685 | 2017-11-20 | Filing | |
| $128.35 | 3 | $385.05 | 1,686 | 2017-07-28 | Filing | |
| $130.24 | 3 | $390.72 | 1,683 | 2017-07-17 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $480.75 | 7,875 | $3,785,934.60 | 0 | 2026-02-17 | Filing | |
| $480.75 | 14,625 | $7,031,021.40 | 0 | 2026-02-17 | Filing | |
| $474.68 | 50 | $23,734.00 | 220 | 2026-02-17 | Filing | |
| $474.65 | 7,875 | $3,737,890.01 | 0 | 2026-02-09 | Filing | |
| $474.65 | 14,625 | $6,941,795.74 | 0 | 2026-02-09 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 5,170,766 | $2,519,455,839 | 0.04% | |
| 2. | 4,176,016 | $2,034,763,797 | 0.03% | |
| 3. | 2,441,492 | $1,189,616,979 | 0.21% | |
| 4. | 1,842,411 | $897,714,760 | 0.03% | |
| 5. | 1,193,064 | $580,238,360 | 0.04% |