| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Renaissance Technologies Jim Simons | 2,173,392 | $911,107,660 | +3% | 1.2% |
| 2. | VenBio Select Advisor Kurt Von Emster | 2,022,222 | $847,735,685 | -15% | 10.96% |
| 3. | AQR Capital Management Cliff Asness | 986,478 | $413,541,523 | -23% | 0.27% |
| 4. | Darwin Global Management Abhishek Trehan | 748,550 | $317,617,251 | 8.83% | |
| 5. | Deerfield Management James E. Flynn | 425,993 | $178,580,526 | -22% | 2.73% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $82.83 | 4 | $331.32 | 1,684 | 2019-06-10 | Filing | |
| $114.06 | 6 | $684.36 | 1,686 | 2018-04-20 | Filing | |
| $126.20 | 5 | $631.00 | 1,685 | 2017-11-20 | Filing | |
| $128.35 | 3 | $385.05 | 1,686 | 2017-07-28 | Filing | |
| $130.24 | 3 | $390.72 | 1,683 | 2017-07-17 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $482.29 | 131 | $63,180.61 | 8,142 | 2025-11-24 | Filing | |
| $481.55 | 794 | $382,353.96 | 8,273 | 2025-11-24 | Filing | |
| $480.71 | 640 | $307,654.59 | 9,067 | 2025-11-24 | Filing | |
| $478.73 | 315 | $150,800.27 | 9,707 | 2025-11-24 | Filing | |
| $478.14 | 1,630 | $779,361.52 | 10,022 | 2025-11-24 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 5,352,996 | $2,244,029,549 | 0.04% | |
| 2. | 4,418,610 | $1,852,325,498 | 0.03% | |
| 3. | 1,922,609 | $805,976,919 | 0.03% | |
| 4. | 1,398,781 | $586,382,984 | 0.1% | |
| 5. | 1,249,660 | $522,908,608 | 0.03% |