Biotechs offer the possibility of monster returns. Overnight doubles aren’t out of the question. Triples and quadruples as a drug successfully progresses through the clinical trial process are the norm.
And yet many investors shy away from the industry. Let’s take a look at why.
Down on bad news
Biotechs face many succeed-or-fail binary events over the course of drug development. Clinical trials, Food and Drug Administration advisory committee meetings, and FDA approval decisions all offer an opportunity for a monster pop or a monster drop.
As drugs succeed, they’re given a larger value, but that means if a drug subsequently fails, it has a larger effect on the stock price. Phase 1 failures tend to have very little effect on stock prices. Phase 2 hurts a little more, especially for companies with limited pipelines. Drugs that fail in phase 3 are quite costly.
For example, shares of ZIOPHARM Oncology Inc. (NASDAQ:ZIOP) were cut by two-thirds this week after its cancer drug palifosfamide failed a phase 3 trial in metastatic soft tissue sarcoma. The smaller phase 2 trial suggested the drug was working, which built up the value of the company. The drug did delay tumor progression by a month, but the increase wasn’t statistically significant.
Down on good news
These days, it doesn’t take bad news to send shares down. Good-but-expected news is often enough to do it. After the excitement of the binary event is over, investors flee. It’s “sell the news” without the “buy the rumor.”
For example, Navidea Biopharmaceuticals Inc (NYSEMKT:NAVB) dropped 12% following the approval of its lymph node diagnostic Lymphoseek this month. The approval was widely expected after an earlier FDA rejection for issues at a third-party manufacturer.
In December, Ariad Pharmaceuticals, Inc. (NASDAQ:ARIA) experienced the same issue with a double-digit drop after its leukemia drug Iclusig was approved by the FDA. Strong data and a fast-track designation got the drug approved quickly.
Down on unexpected news
The worst risk is the kind that can’t be foreseen.
At least with binary events, investors can see it coming. Data from a clinical trial will be released. The FDA will make a decision about whether the drug is approvable. The exact date might not be known, but at least it can be pinpointed to a month or two, with many events coming in a smaller window than that.
But sometimes events come out of left field. And they’re almost never the good kind.
Shares of Affymax, Inc. (NASDAQ:AFFY), for instance, are down more than 90% year to date after the company had to recall all of its red blood cell stimulating drug, Omontys, that treats patients on dialysis with chronic kidney disease. The drug caused allergic reaction in some patients, which was occasionally fatal.
Didn’t you say something about monster returns?
While there’s a lot of risk investing in the biotech industry, there’s also the potential for insane increases in share prices. Regeneron Pharmaceuticals Inc (NASDAQ:REGN) , for instance is up 550% over the last 3 years thanks to the successful development and launch of its macular degeneration drug Eylea.