5 Cities with the Highest Opioid Deaths in the U.S.

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1. Baltimore, Maryland

Opioid-related drug overdose deaths (per 100,000 population, age-adjusted): 109.5

Baltimore has a population of more than half a million people and it is the largest city in Maryland. It was founded in 1730, well before the American Revolution. It is a hub for world trade in its state and renowned for its Johns Hopkins Hospital.

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