13G Filing: Great Point Partners and PTC Therapeutics Inc. (PTCT)

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Ownership Summary Table

Name Sole Voting Power Shared Voting Power Sole Dispositive Power Shared Dispositive Power Aggregate Amount Owned Power Percent of Class
Great Point Partners 0 2,160,000 0 2,160,000 2,160,000 5.24%
Dr. Jeffrey R. Jay, M.D 0 2,160,000 0 2,160,000 2,160,000 5.24%
Mr. David Kroin 0 2,160,000 0 2,160,000 2,160,000 5.24%

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Page 1 of 10 – SEC Filing

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

Schedule 13G

Under the Securities Exchange Act of
1934

(Amendment No. )*

PTC Therapeutics Inc.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

69366J200

(CUSIP Number)

June 6, 2017

(Date of Event which Requires Filing of
this Statement)

Check the appropriate box to designate the
rule pursuant to which this Schedule is filed:

x Rule 13d-1(b)
o Rule 13d-1(c)
o Rule 13d-1(d)

*The remainder of this
cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover
page.

The information required in the remainder
of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of
1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).

Persons who respond to the collection of
information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

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Page 2 of 10 – SEC Filing

CUSIP
No.
69366J200
13G Page
2 of 9 Pages
1.

NAMES OF REPORTING PERSONS

Great Point Partners, LLC

I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):

37-1475292

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) o
(b) o
3. SEC USE ONLY
4.

CITIZENSHIP OR PLACE OF ORGANIZATION

USA

NUMBER OF SHARES

BENEFICIALLY

OWNED BY EACH

REPORTING PERSON

WITH
5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

2,160,0001

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

2,160,0001

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

2,160,0001

10.

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES
(See Instructions)

o
11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

5.24%2

12.

TYPE OF REPORTING PERSON (See Instructions)

IA

1 Includes options exercisable on or before December 15, 2017 to purchase 260,000 shares at an exercise price of $18 per share; provided that the filing of this Schedule 13G shall not be deemed to be an admission that any reporting person beneficially owns the shares underlying such options.
2 Based on a total of 41,244,004 shares outstanding, as reported by the Issuer on a Form 10Q filed with the SEC on May 5, 2017.

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Page 3 of 10 – SEC Filing

CUSIP
No.
69366J200
13G Page
3 of 9 Pages
1.

NAMES OF REPORTING PERSONS

Dr. Jeffrey R. Jay, M.D.

I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) o
(b) o
3. SEC USE ONLY
4.

CITIZENSHIP OR PLACE OF ORGANIZATION

USA

NUMBER OF SHARES

BENEFICIALLY

OWNED BY EACH

REPORTING PERSON

WITH
5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

2,160,0001

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

2,160,0001

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

2,160,0001

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) o
11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

5.24%2

12.

TYPE OF REPORTING PERSON (See Instructions)

IN

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Page 4 of 10 – SEC Filing

CUSIP
No.
69366J200
13G Page
4 of 9 Pages
1.

NAMES OF REPORTING PERSONS

Mr. David Kroin

I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) o
(b) o
3. SEC USE ONLY
4.

CITIZENSHIP OR PLACE OF ORGANIZATION

USA

NUMBER OF SHARES

BENEFICIALLY

OWNED BY EACH

REPORTING PERSON

WITH
5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

2,160,0001

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

2,160,0001

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

2,160,0001

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) o
11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

5.24%2

12.

TYPE OF REPORTING PERSON (See Instructions)

IN

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Page 5 of 10 – SEC Filing

CUSIP
No.
69366J200
13G Page
5 of 9 Pages
Item 1.
(a) Name of Issuer
PTC Therapeutics Inc.
(b) Address of Issuer’s Principal Executive Offices
100 Corporate Court, South Plainfield, NJ 07080-2449
Item 2.
(a) Name of Person Filing
Great Point Partners, LLC
Dr. Jeffrey R. Jay, M.D.
Mr. David Kroin
The Reporting Persons have entered into a Joint Filing
Agreement, dated June 16, 2017, a copy of which is filed with this Schedule 13G as Exhibit A, pursuant to which the Reporting
Persons have agreed to file this statement jointly in accordance with the provisions of Rule 13d-1(k)(1) under the Act.
(b) Address of Principal Business Office, or if none, Residence
The address of the principal business office of each of the Reporting
Persons is
165 Mason Street, 3rd Floor
Greenwich, CT 06830
(c) Citizenship
Great Point Partners, LLC is a limited liability company
organized under the laws of the State of Delaware. Dr. Jeffrey R. Jay, M.D. is a citizen of the United States. Mr. David Kroin
is a citizen of the United States.
(d) Title of Class of Securities
Common Stock
(e) CUSIP Number
69366J200
Item 3. If this statement is filed pursuant to §240.13d-1(b) or 240.13d.2(b) or (c), check whether the person
filing is a:
Not Applicable.
(a) o Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o)
(b) o Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).
(c) o Insurance company as defined in Section 3(a)(19) of the Act (15. U.S.C. 78c).
(d) o Investment Company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).
(e) x An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E).

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Page 6 of 10 – SEC Filing

CUSIP
No.
69366J200
13G Page
6 of 9 Pages
(f) o An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F).
(g) o A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G).
(h) o A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813).
(i) o A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company
Act of 1940 (15 U.S.C. 80a-3).
(j) o Group, in accordance with §240.13d-1(b)(1)(ii)(J).
Item 4. Ownership
Biomedical Value Fund, L.P. (“BVF”) is the record owner of 524,399 shares (the “BVF Shares”)
and options exercisable on or before December 15, 2017 to purchase 71,800 shares at an exercise price of $18 per share (the
“BVF Options” and together with the BVF Shares, the “BVF Equity”). Great Point Partners, LLC (“Great
Point”) is the investment manager of BVF, and by virtue of such status may be deemed to be the beneficial owner of the
BVF Equity. Each of Dr. Jeffrey R. Jay, M.D. (“Dr. Jay”), as senior managing member of Great Point, and Mr. David
Kroin (“Mr. Kroin”), as special managing member of Great Point, has voting and investment power with respect to
the BVF Equity, and therefore may be deemed to be the beneficial owner of the BVF Equity.
Biomedical Offshore Value Fund, Ltd. (“BOVF”) is the record owner of 805,601 shares (the “BOVF
Shares”) and options exercisable on or before December 15, 2017 to purchase 110,200 shares at an exercise price of $18
per share (the “BOVF Options” and together with the BOVF Shares, the “BOVF Equity”). Great Point is
the investment manager of BOVF, and by virtue of such status may be deemed to be the beneficial owner of the BOVF Equity.
Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting
and investment power with respect to the BOVF Equity, and therefore may be deemed to be the beneficial owner of the BOVF Equity.
GEF-SMA, L.P. (“GEF-SMA”) is the record owner of 570,000 shares (the “GEF-SMA Shares”)
and options exercisable on or before December 15, 2017 to purchase 78,000 shares at an exercise price of $18 per share (the
“GEF-SMA Options” and together with the GEF-SMA Shares, the “GEF-SMA Equity”). Great Point is the
investment manager with respect to the GEF-SMA Equity, and by virtue of such status may be deemed to be the beneficial owner
of the GEF-SMA Equity. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member
of Great Point, has voting and investment power with respect to the GEF-SMA Equity, and therefore may be deemed to be the
beneficial owner of the GEF-SMA Equity.
Notwithstanding the above, Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Equity,
the BOVF Equity and the GEF-SMA Equity, except to the extent of their respective pecuniary interests.
The filing of this Schedule 13G shall not be deemed to be an admission that Great Point, Dr. Jay or Mr. Kroin
beneficially owns the shares underlying the BVF Options, the BOVF Options or the GEF-SMA Options.
Provide the following information regarding the aggregate number and percentage of the class of securities
of the issuer identified in Item 1.

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Page 7 of 10 – SEC Filing

CUSIP
No.
69366J200
13G Page
7 of 9 Pages
1. Great Point Partners, LLC
(a) Amount beneficially owned:  2,160,0001
(b) Percent of class:  5.24%2
(c) Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:  0
(ii) Shared power to vote or to direct the vote:  2,160,0001
(iii) Sole power to dispose or to direct the disposition of: 0
(iv) Shared power to dispose or to direct the disposition of:  2,160,0001
2. Dr. Jeffrey R. Jay, M.D.
(a) Amount beneficially owned:  2,160,0001
(b) Percent of class:  5.24%2
(c) Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:  0
(ii) Shared power to vote or to direct the vote: 2,160,0001
(iii) Sole power to dispose or to direct the disposition of:  0
(iv) Shared power to dispose or to direct the disposition of:  2,160,0001
3. Mr. David Kroin
(a) Amount beneficially owned:  2,160,0001
(b) Percent of class:  5.24%2
(c) Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:  0
(ii) Shared power to vote or to direct the vote:  2,160,0001
(iii) Sole power to dispose or to direct the disposition of:  0
(iv) Shared power to dispose or to direct the disposition of:  2,160,0001
Item 5. Ownership of Five Percent or Less
of a Class

If this statement is
being filed to report the fact that as of the date hereof each of the Reporting Persons has ceased to be the beneficial owner of
more than five percent of the class of securities, check the following [__].

Item 6. Ownership of More than Five Percent
on Behalf of Another Person:
See Item 4.
Item 7. Identification and Classification
of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company
Not Applicable.

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Page 8 of 10 – SEC Filing

CUSIP
No.
69366J200
13G Page
8 of 9 Pages
Item 8. Identification and Classification
of Members of the Group
Not Applicable.
Item 9. Notice of Dissolution of Group
Not Applicable.
Item 10. Certification

By signing below I certify
that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not
held in connection with or as participant in any transaction having that purpose or effect.

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Page 9 of 10 – SEC Filing

CUSIP
No.
69366J200
13G Page
9 of 9 Pages

SIGNATURE

After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: June 16, 2017

GREAT POINT PARTNERS, LLC
By: /s/ Dr. Jeffrey R. Jay, M.D.
Dr. Jeffrey R. Jay, M.D.,
  as senior managing member
/s/ Dr. Jeffrey R. Jay, M.D.
DR. JEFFREY R. JAY, M.D.
/s/ Mr. David Kroin
MR. DAVID KROIN

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Page 10 of 10 – SEC Filing

Exhibit
A

AGREEMENT REGARDING THE JOINT FILING
OF SCHEDULE 13G

The undersigned hereby agree as follows:

(i)          Each
of them is individually eligible to use the Schedule 13G to which this Exhibit is attached, and such Schedule 13G is filed on behalf
of each of them; and

(ii)         Each
of them is responsible for the timely filing of such Schedule 13G and any amendments thereto, and for the completeness and accuracy
of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of
the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information
is inaccurate.

Date: June 16, 2017

GREAT POINT PARTNERS, LLC
By: /s/ Dr. Jeffrey R. Jay, M.D.
Dr. Jeffrey R. Jay, M.D.,
  as senior managing member
/s/ Dr. Jeffrey R. Jay, M.D.
DR. JEFFREY R. JAY, M.D.
/s/ Mr. David Kroin
MR. DAVID KROIN

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