| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 2,590,303 | $99,830,278 | 4.05% | |
| 2. | Opaleye Management James A. Silverman | 255,087 | $9,831,053 | 1.39% | |
| 3. | Woodline Partners Michael Rockefeller And Karl Kroeker | 209,945 | $8,091,280 | +17% | 0.04% |
| 4. | Stonepine Capital Timothy P. Lynch | 115,459 | $4,449,790 | -25% | 3.62% |
| 5. | HighVista Strategies Andre F. Perold | 105,714 | $4,074,218 | -8% | 1% |