| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Renaissance Technologies Jim Simons | 1,004,888 | $447,376,138 | -15% | 0.6% |
| 2. | 318,800 | $141,929,760 | +16% | 0.02% | |
| 3. | OrbiMed Advisors Samuel Isaly | 210,287 | $93,619,772 | +32% | 2.34% |
| 4. | Adage Capital Management Phill Gross And Robert Atchinson | 178,192 | $79,331,078 | -64% | 0.13% |
| 5. | Squarepoint Ops LLC Maxime Fortin (Cio) | 175,687 | $78,215,852 | +2449% | 0.08% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $389.95 | 5,710 | $2,226,614.50 | 115,968 | 2025-08-06 | Filing | |
| $389.08 | 4,290 | $1,669,153.20 | 110,258 | 2025-08-06 | Filing | |
| $389.84 | 3,366 | $1,312,201.44 | 45,000 | 2025-08-06 | Filing | |
| $389.36 | 1,634 | $636,214.24 | 41,634 | 2025-08-06 | Filing | |
| $196.34 | 4,243 | $833,070.62 | 73,754 | 2021-08-19 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $404.21 | 694 | $280,521.74 | 15,653 | 2025-10-02 | Filing | |
| $386.69 | 266 | $102,859.54 | 4,565 | 2025-08-27 | Filing | |
| $424.69 | 52 | $22,083.88 | 23,281 | 2025-05-15 | Filing | |
| $505.86 | 400 | $202,344.00 | 4,831 | 2025-05-02 | Filing | |
| $510.00 | 3,231 | $1,647,810.00 | 23,281 | 2025-03-13 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 763,703 | $299,096,643 | 0.41% | |
| 2. | 432,257 | $168,845,835 | 0.17% | |
| 3. | 160,875 | $63,005,065 | 0.42% | |
| 4. | 65,118 | $25,502,814 | 0.18% | |
| 5. | 40,977 | $16,048,232 | 0.27% |
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