Spyre Therapeutics Inc. (SYRE)

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Institutional Investors' Holdings

Filing Period: Filing is Ongoing

No.	Name	Shares	Value	% Port
1.	Geode Capital Management, Llc	1,227,232	$18,373,490	0%
2.	Emerald Advisers Inc	565,863	$8,470,969	0.31%
3.	Emerald Mutual Fund Advisers Trust	329,430	$4,931,567	0.3%
4.	Candriam Luxembourg S.c.a.	246,030	$3,683,226	0.02%
5.	Bank Of New York Mellon Corp	132,150	$1,978,285	0%