Spyre Therapeutics Inc. (SYRE)

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Institutional Investors' Holdings

Filing Period: Filing is Ongoing

No.	Name	Shares	Value	% Port
1.	Blackrock, Inc.	3,572,674	$57,645,096	0%
2.	Vanguard Group Inc	2,898,267	$46,763,538	0%
3.	Pictet Asset Management Holding Sa	1,068,892	$17,246,572	0.02%
4.	Emerald Advisers Inc	547,827	$8,839,189	0.4%
5.	Emerald Mutual Fund Advisers Trust	389,422	$6,283,324	0.45%