Spyre Therapeutics Inc. (SYRE)

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Institutional Investors' Holdings

Filing Period: Filing is Ongoing

No.	Name	Shares	Value	% Port
1.	Vanguard Group Inc	3,050,730	$51,130,235	0%
2.	Emerald Advisers Inc	548,712	$9,196,413	0.29%
3.	Candriam Luxembourg S.c.a.	404,362	$6,777,107	0.04%
4.	Emerald Mutual Fund Advisers Trust	308,212	$5,165,633	0.27%
5.	Jpmorgan Chase & Co	275,984	$4,625,492	0%