One Company's Clinical Miss Is Another's Moat: Vertex Rallies as Sionna's CF Bet Collapses
Cystic fibrosis investors came to learn a harsh lesson on August 10 about how concentrated a market can be: Sionna Therapeutics, Inc.
| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | RA Capital Management Peter Kolchinsky | 9,905,045 | $435,722,930 | 3.79% | |
| 2. | Viking Global Andreas Halvorsen | 3,195,181 | $140,556,012 | 0.4% | |
| 3. | OrbiMed Advisors Samuel Isaly | 2,555,877 | $112,433,029 | -28% | 2.08% |
| 4. | Enavate Sciences James Boylan | 2,478,030 | $109,008,540 | 31.56% | |
| 5. | Adage Capital Management Phill Gross And Robert Atchinson | 1,600,000 | $70,384,000 | +967% | 0.1% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $15.84 | 60,000 | $950,400.00 | 6,744,962 | 2025-06-27 | Filing | |
| $18.00 | 1,125,000 | $20,250,000.00 | 6,684,962 | 2025-02-10 | Filing | |
| $18.00 | 102,414 | $1,843,452.00 | 2,324,498 | 2025-02-10 | Filing | |
| $18.00 | 1,022,586 | $18,406,548.00 | 6,923,365 | 2025-02-10 | Filing | |
| $18.00 | 550,000 | $9,900,000.00 | 3,704,959 | 2025-02-10 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $44.86 | 85,918 | $3,854,281.48 | 2,469,959 | 2026-07-07 | Filing | |
| $44.86 | 85,918 | $3,854,281.48 | 2,469,959 | 2026-07-07 | Filing | |
| $43.60 | 10,250 | $446,862.08 | 0 | 2026-07-06 | Filing | |
| $45.50 | 115,844 | $5,270,902.00 | 2,555,877 | 2026-06-30 | Filing | |
| $45.50 | 115,844 | $5,270,902.00 | 2,555,877 | 2026-06-30 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 6,494,962 | $285,713,378 | 5.71% | |
| 2. | 2,995,602 | $131,776,532 | 14.95% | |
| 3. | 1,474,769 | $64,875,089 | 0% | |
| 4. | 1,490,508 | $64,085,673 | 0% | |
| 5. | 1,172,133 | $51,562,131 | 0.03% |