| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Siren L.L.C. Raymond Debbane | 9,250,005 | $327,635,177 | 16.95% | |
| 2. | Samsara BioCapital Srini Akkaraju And Michael Dybbs | 5,612,896 | $198,808,776 | 40.66% | |
| 3. | Redmile Group Jeremy Green | 3,929,039 | $139,166,561 | -11% | 14.81% |
| 4. | Hood River Capital Management David Swank | 1,974,964 | $69,953,225 | +2% | 0.98% |
| 5. | Marshall Wace LLP Paul Marshall And Ian Wace | 1,640,437 | $58,104,278 | +1% | 0.07% |