| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Farallon Capital Thomas Steyer | 14,625,692 | $683,019,816 | +3% | 2.8% |
| 2. | Baker Bros. Advisors Julian Baker And Felix Baker | 9,455,357 | $441,565,172 | +1% | 3.19% |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 3,974,913 | $185,628,437 | -21% | 7.52% |
| 4. | Deerfield Management James E. Flynn | 3,650,342 | $170,470,971 | +8% | 2.6% |
| 5. | Holocene Advisors Brandon Haley | 3,437,283 | $160,521,116 | -6% | 0.37% |