| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 9,426,640 | $113,214 | 6.08% | |
| 2. | OrbiMed Advisors Samuel Isaly | 1,797,458 | $21,587 | -50% | 0.18% |
| 3. | Palo Alto Investors William Leland Edwards | 1,691,805 | $20,319 | +28% | 1.06% |
| 4. | Ikarian Capital Neil Shahrestani | 1,186,700 | $14,252 | 0.62% | |
| 5. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 1,141,100 | $13,705 | +12% | 0.29% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $22.02 | 10,800 | Large Shareholder | 10,159,280 | 2021-02-24 | Filing | |
| $21.05 | 44,400 | Large Shareholder | 10,148,480 | 2021-02-23 | Filing | |
| $23.65 | 44,100 | Large Shareholder | 10,104,080 | 2021-02-18 | Filing | |
| $3.68 | 44,100 | Large Shareholder | 10,104,080 | 2021-02-18 | Filing | |
| $23.46 | 198,840 | Large Shareholder | 10,059,980 | 2021-02-17 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $25.50 | 7,540 | Officer | 0 | 2021-02-18 | Filing | |
| $20.00 | 18,750 | Officer | 0 | 2021-02-12 | Filing | |
| $17.07 | 7,560 | Officer | 0 | 2021-02-12 | Filing | |
| $64.77 | 201 | Director | 2,845 | 2017-10-02 | Filing | |
| $64.13 | 3,299 | Director | 3,046 | 2017-10-02 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 36,107 | $360,709 | 0% | |
| 2. | 6,082 | $73,045 | 0% | |
| 3. | 3,692,970 | $44,351 | 0% | |
| 4. | 2,056,453 | $24,698 | 1.82% | |
| 5. | 1,737,969 | $20,874 | 0% |
