| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 9,426,640 | $149,224 | 13.45% | |
| 2. | Great Point Partners Jeffrey Jay And David Kroin | 2,100,941 | $33,258 | +2% | 2.89% |
| 3. | Lonestar Capital Management Jerome L. Simon | 300,000 | $4,749 | 2.85% | |
| 4. | Palo Alto Investors William Leland Edwards | 992,749 | $15,715 | -2% | 0.86% |
| 5. | Tang Capital Management Kevin C. Tang | 423,823 | $6,709 | 0.8% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $51.32 | 1,000 | Officer | 3,200 | 2017-03-09 | Filing | |
| $19.12 | 2,000 | Officer | 2,000 | 2014-08-07 | Filing | |
| $19.54 | 2,500 | Officer | 2,793 | 2014-05-09 | Filing | |
| $19.61 | 2,200 | Officer | 2,200 | 2014-05-09 | Filing | |
| $21.00 | 1,656 | Officer | 2,000 | 2014-05-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $64.77 | 201 | Director | 2,845 | 2017-10-02 | Filing | |
| $64.13 | 3,299 | Director | 3,046 | 2017-10-02 | Filing | |
| $69.20 | 12,776 | Officer | 2,000 | 2017-09-28 | Filing | |
| $69.05 | 4,724 | Officer | 2,000 | 2017-09-27 | Filing | |
| $70.00 | 1,500 | Officer | 0 | 2017-09-28 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 300,000 | $4,749 | 0.18% | |
| 2. | 45,362 | $718 | 0.06% | |
| 3. | 16,476 | $261 | 0.06% | |
| 4. | 118,771 | $1,880 | 0.05% | |
| 5. | 314,325 | $4,976 | 0.04% |
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