| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | 70,000,000 | $168,190,750 | 2.57% | ||
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,495,290 | $109,619,710 | -46% | 4.44% |
| 3. | Tang Capital Management Kevin C. Tang | 1,236,027 | $90,613,139 | 3.49% | |
| 4. | Citadel Investment Group Ken Griffin | 1,040,544 | $76,282,281 | -27% | 0.01% |
| 5. | D E Shaw D. E. Shaw | 923,509 | $67,702,445 | +67% | 0.04% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $68.48 | 131,425 | $8,999,984.00 | 459,010 | 2026-01-23 | Filing | |
| $43.93 | 21 | $922.61 | 168,672 | 2025-03-17 | Filing | |
| $44.11 | 528 | $23,291.40 | 168,651 | 2025-03-14 | Filing | |
| $43.77 | 963 | $42,155.13 | 168,123 | 2025-03-11 | Filing | |
| $43.37 | 577 | $25,023.34 | 167,160 | 2025-03-10 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $103.30 | 2,631 | $271,791.51 | 20,655 | 2026-02-02 | Filing | |
| $103.30 | 9,108 | $940,888.28 | 160,294 | 2026-02-02 | Filing | |
| $103.30 | 968 | $99,997.79 | 4,503 | 2026-02-02 | Filing | |
| $96.19 | 1,053 | $101,290.18 | 43,741 | 2026-01-26 | Filing | |
| $96.19 | 3,143 | $302,331.46 | 23,286 | 2026-01-26 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 2,596,089 | $205,065,069 | 0% | |
| 2. | 25,532,000 | $65,982,855 | 2.31% | |
| 3. | 577,274 | $45,598,873 | 0.04% | |
| 4. | 320,783 | $25,338,649 | 0% | |
| 5. | 227,479 | $17,968,566 | 1.42% |
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