| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | 70,000,000 | $168,190,750 | 2.57% | ||
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,495,290 | $109,619,710 | -46% | 4.44% |
| 3. | Tang Capital Management Kevin C. Tang | 1,236,027 | $90,613,139 | 3.49% | |
| 4. | Citadel Investment Group Ken Griffin | 1,040,544 | $76,282,281 | -27% | 0.01% |
| 5. | D E Shaw D. E. Shaw | 923,509 | $67,702,445 | +67% | 0.04% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $43.93 | 21 | $922.61 | 168,672 | 2025-03-17 | Filing | |
| $44.11 | 528 | $23,291.40 | 168,651 | 2025-03-14 | Filing | |
| $43.77 | 963 | $42,155.13 | 168,123 | 2025-03-11 | Filing | |
| $43.37 | 577 | $25,023.34 | 167,160 | 2025-03-10 | Filing | |
| $42.66 | 758 | $32,339.46 | 166,583 | 2025-03-10 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $74.00 | 50,000 | $3,700,000.00 | 0 | 2025-12-01 | Filing | |
| $70.00 | 50,000 | $3,500,000.00 | 0 | 2025-11-21 | Filing | |
| $75.07 | 1,491 | $111,929.37 | 15,703 | 2025-09-11 | Filing | |
| $74.34 | 15,509 | $1,152,939.06 | 17,194 | 2025-09-11 | Filing | |
| $76.01 | 9,578 | $728,023.78 | 39,945 | 2025-09-12 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 6,795,121 | $498,150,321 | 14.93% | |
| 2. | 4,997,586 | $366,518,621 | 0.17% | |
| 3. | 3,602,434 | $264,094,437 | 0% | |
| 4. | 2,545,369 | $186,601,001 | 0% | |
| 5. | 2,522,563 | $184,923,401 | 3.04% |