| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Tang Capital Management Kevin C. Tang | 1,236,027 | $144,701,681 | 6.57% | |
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,056,027 | $123,629,081 | -34% | 3.16% |
| 3. | Polar Capital Brian Ashford-Russell And Tim Woolley | 845,524 | $98,985,495 | +199% | 0.23% |
| 4. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 798,145 | $93,438,835 | -2% | 4.56% |
| 5. | Woodline Partners Michael Rockefeller And Karl Kroeker | 567,894 | $66,483,351 | 0.21% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $68.48 | 131,425 | $8,999,984.00 | 459,010 | 2026-01-23 | Filing | |
| $43.93 | 21 | $922.61 | 168,672 | 2025-03-17 | Filing | |
| $44.11 | 528 | $23,291.40 | 168,651 | 2025-03-14 | Filing | |
| $43.77 | 963 | $42,155.13 | 168,123 | 2025-03-11 | Filing | |
| $43.37 | 577 | $25,023.34 | 167,160 | 2025-03-10 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $98.37 | 9,943 | $978,092.91 | 44,745 | 2026-09-14 | Filing | |
| $100.00 | 658 | $65,800.00 | 616 | 2026-09-02 | Filing | |
| $98.91 | 21,688 | $2,145,160.08 | 194,440 | 2026-09-01 | Filing | |
| $98.08 | 8,312 | $815,240.96 | 216,128 | 2026-09-01 | Filing | |
| $100.00 | 40,000 | $4,000,000.00 | 1,274 | 2026-08-18 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 7,679,684 | $899,060,606 | 19.58% | |
| 2. | 5,909,184 | $691,671,568 | 0.28% | |
| 3. | 4,390,063 | $513,944,677 | 0.01% | |
| 4. | 3,670,314 | $429,683,688 | 0.02% | |
| 5. | 2,377,019 | $278,277,614 | 0.01% |
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