| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 0 | $0 | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $10.00 | 10,000 | Director | 10,000 | 2014-07-08 | Filing | |
| $10.00 | 75,000 | Director | 325,645 | 2014-07-08 | Filing | |
| $10.00 | 5,000 | Officer, Director | 5,000 | 2014-07-08 | Filing | |
| $10.00 | 85,000 | Director | 267,894 | 2014-07-08 | Filing | |
| $10.00 | 130,000 | Large Shareholder | 530,461 | 2014-07-08 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $1.67 | 26,188 | Director | 241,706 | 2016-03-17 | Filing | |
| $1.55 | 11,000 | Director | 463,267 | 2016-03-18 | Filing | |
| $1.52 | 158 | Director | 836 | 2016-03-17 | Filing | |
| $1.52 | 12,468 | Director | 65,958 | 2016-03-17 | Filing | |
| $1.85 | 112 | Director | 994 | 2016-03-16 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 0 | $0 | 0% | |
| 2. | 0 | $0 | 0% | |
| 3. | 0 | $0 | 0% | |
| 4. | 0 | $0 | 0% | |
| 5. | 0 | $0 | 0% |
