| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 6,929,690 | $34,510 | 3.36% | |
| 2. | Great Point Partners Jeffrey Jay And David Kroin | 1,537,020 | $7,654 | -9% | 1.08% |
| 3. | OrbiMed Advisors Samuel Isaly | 5,000,000 | $24,900 | 0.29% | |
| 4. | Algert Coldiron Investors Peter Algert And Kevin Coldiron | 218,023 | $1,086 | 0.22% | |
| 5. | Opaleye Management James A. Silverman | 161,400 | $803 | 0.2% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.00 | 699,225 | Large Shareholder | 1,295,582 | 2018-02-09 | Filing | |
| $3.00 | 483,708 | Large Shareholder | 483,708 | 2018-02-09 | Filing | |
| $3.00 | 2,109,280 | Large Shareholder | 2,109,280 | 2018-02-09 | Filing | |
| $3.00 | 3,041,120 | Large Shareholder | 3,041,120 | 2018-02-09 | Filing | |
| $1.22 | 58,613 | Large Shareholder | 17,263,200 | 2016-01-08 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.20 | 976 | Director | 73,718 | 2017-09-29 | Filing | |
| $3.25 | 200 | Director | 74,694 | 2017-09-28 | Filing | |
| $3.24 | 477 | Director | 74,894 | 2017-09-28 | Filing | |
| $3.24 | 200 | Director | 75,371 | 2017-09-28 | Filing | |
| $3.23 | 1,600 | Director | 75,571 | 2017-09-28 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 4,049,298 | $20,166 | 12.25% | |
| 2. | 874,407 | $4,355 | 0.6% | |
| 3. | 123,976 | $617 | 0.16% | |
| 4. | 394,505 | $1,965 | 0.03% | |
| 5. | 277,006 | $1,452 | 0.03% |
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