| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 9,520,600 | $30,656 | 0.26% | |
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 6,929,690 | $22,314 | 0.87% | |
| 3. | Consonance Capital Management Mitchell Blutt | 2,512,800 | $8,091 | 0.75% | |
| 4. | Stonepine Capital Timothy P. Lynch | 2,054,000 | $6,614 | -46% | 5.06% |
| 5. | Renaissance Technologies Jim Simons | 1,799,171 | $5,793 | -19% | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.00 | 699,225 | Large Shareholder | 1,295,582 | 2018-02-09 | Filing | |
| $3.00 | 483,708 | Large Shareholder | 483,708 | 2018-02-09 | Filing | |
| $3.00 | 2,109,280 | Large Shareholder | 2,109,280 | 2018-02-09 | Filing | |
| $3.00 | 3,041,120 | Large Shareholder | 3,041,120 | 2018-02-09 | Filing | |
| $1.22 | 58,613 | Large Shareholder | 17,263,200 | 2016-01-08 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.50 | 2,000,000 | Large Shareholder | 7,520,600 | 2021-01-07 | Filing | |
| $3.20 | 976 | Director | 73,718 | 2017-09-29 | Filing | |
| $3.25 | 200 | Director | 74,694 | 2017-09-28 | Filing | |
| $3.24 | 477 | Director | 74,894 | 2017-09-28 | Filing | |
| $3.24 | 200 | Director | 75,371 | 2017-09-28 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 7,140,450 | $22,992 | 0.6% | |
| 2. | 3,749,890 | $12,075 | 7.52% | |
| 3. | 2,962,312 | $9,538 | 0% | |
| 4. | 989,602 | $3,187 | 0.02% | |
| 5. | 910,037 | $2,931 | 0% |
