| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 6,929,690 | $14,968 | 1.31% | |
| 2. | Opaleye Management James A. Silverman | 1,550,000 | $3,348 | +861% | 0.85% |
| 3. | Algert Coldiron Investors Peter Algert And Kevin Coldiron | 339,349 | $733 | +56% | 0.15% |
| 4. | OrbiMed Advisors Samuel Isaly | 5,000,000 | $10,800 | 0.13% | |
| 5. | Millennium Management Israel Englander | 0 | $0 | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.00 | 699,225 | Large Shareholder | 1,295,582 | 2018-02-09 | Filing | |
| $3.00 | 483,708 | Large Shareholder | 483,708 | 2018-02-09 | Filing | |
| $3.00 | 2,109,280 | Large Shareholder | 2,109,280 | 2018-02-09 | Filing | |
| $3.00 | 3,041,120 | Large Shareholder | 3,041,120 | 2018-02-09 | Filing | |
| $1.22 | 58,613 | Large Shareholder | 17,263,200 | 2016-01-08 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.20 | 976 | Director | 73,718 | 2017-09-29 | Filing | |
| $3.25 | 200 | Director | 74,694 | 2017-09-28 | Filing | |
| $3.24 | 477 | Director | 74,894 | 2017-09-28 | Filing | |
| $3.24 | 200 | Director | 75,371 | 2017-09-28 | Filing | |
| $3.23 | 1,600 | Director | 75,571 | 2017-09-28 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 4,145,459 | $8,954 | 5.62% | |
| 2. | 3,750,000 | $8,100 | 0.34% | |
| 3. | 35,665 | $77 | 0.06% | |
| 4. | 568,732 | $1,229 | 0% | |
| 5. | 4,168 | $9 | 0% |
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