| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Casdin Capital Eli Casdin | 750,000 | $58,545 | +19% | 7.11% |
| 2. | Opaleye Management James A. Silverman | 300,000 | $23,418 | -15% | 5.95% |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 598,267 | $46,701 | -8% | 4.1% |
| 4. | DAFNA Capital Management Nathan Fischel | 92,691 | $7,235 | 2.97% | |
| 5. | Hillhouse Capital Management Lei Zhang | 1,430,949 | $111,700 | 2.96% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $18.00 | 125,000 | Large Shareholder, Other | 2,500,711 | 2015-05-05 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $62.66 | 100 | Officer, Director | 0 | 2018-11-05 | Filing | |
| $63.30 | 17,300 | Officer, Director | 100 | 2018-11-05 | Filing | |
| $64.18 | 1,500 | Officer, Director | 17,400 | 2018-11-05 | Filing | |
| $65.53 | 1,100 | Officer, Director | 18,900 | 2018-11-05 | Filing | |
| $70.00 | 1,700 | Officer | 0 | 2018-09-17 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,834 | $99 | 0% | |
| 2. | 0 | $0 | 0% | |
| 3. | 0 | $0 | 0% | |
| 4. | 200 | $11 | 0% | |
| 5. | 94 | $5 | 0% |
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