| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Casdin Capital Eli Casdin | 940,000 | $88,670,200 | +11% | 8.29% |
| 2. | Ghost Tree Capital Ken Greenberg And David Kim | 375,000 | $35,374 | +57% | 7.4% |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 437,565 | $41,276 | -23% | 4.5% |
| 4. | DAFNA Capital Management Nathan Fischel | 123,218 | $11,623 | +3% | 4.36% |
| 5. | Opaleye Management James A. Silverman | 125,000 | $11,791 | -4% | 3.59% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $18.00 | 125,000 | Large Shareholder, Other | 2,500,711 | 2015-05-05 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $75.00 | 415 | Officer | 0 | 2019-10-17 | Filing | |
| $78.14 | 415 | Officer | 0 | 2019-09-16 | Filing | |
| $80.01 | 8,700 | Officer | 0 | 2019-08-21 | Filing | |
| $80.44 | 1,300 | Officer | 0 | 2019-08-20 | Filing | |
| $85.00 | 95 | Officer | 15,865 | 2019-08-19 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 31,845 | $2,340 | 0.64% | |
| 2. | 4,590 | $337 | 0.05% | |
| 3. | 7,238 | $532 | 0.04% | |
| 4. | 7,400 | $543 | 0% | |
| 5. | 100 | $7 | 0% |
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