| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,690,221 | $176,442,170 | 6.3% | |
| 2. | Deep Track Capital David Kroin | 801,371 | $83,655,119 | 2.68% | |
| 3. | GLG Partners Noam Gottesman | 525,069 | $54,811,953 | +3% | 0.1% |
| 4. | Partner Fund Management Christopher Medlock James | 483,105 | $50,431,331 | -14% | 4.29% |
| 5. | Adage Capital Management Phill Gross And Robert Atchinson | 447,000 | $46,662,330 | +832% | 0.08% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $127.40 | 488 | $62,171.20 | 48,212 | 2025-09-08 | Filing | |
| $127.30 | 287 | $36,535.10 | 47,724 | 2025-09-08 | Filing | |
| $127.20 | 800 | $101,760.00 | 47,437 | 2025-09-08 | Filing | |
| $37.30 | 3,950 | $147,350.01 | 120,756 | 2021-11-19 | Filing | |
| $35.20 | 142 | $4,998.40 | 142 | 2021-11-18 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $114.23 | 40,000 | $4,569,200.00 | 0 | 2025-09-16 | Filing | |
| $116.19 | 5,783 | $671,926.77 | 0 | 2025-09-16 | Filing | |
| $114.19 | 19,719 | $2,251,712.61 | 7,229 | 2025-09-16 | Filing | |
| $117.37 | 15,254 | $1,790,361.98 | 7,229 | 2025-09-15 | Filing | |
| $118.96 | 27,907 | $3,319,816.72 | 7,229 | 2025-09-12 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 3,945,020 | $411,820,637 | 0.01% | |
| 2. | 3,834,990 | $400,334,606 | 0.01% | |
| 3. | 1,516,903 | $158,349,504 | 2.26% | |
| 4. | 1,137,748 | $118,770,000 | 0.15% | |
| 5. | 989,453 | $103,302,818 | 0.01% |
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