| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 7,880,094 | $241,288,478 | 11.58% | |
| 2. | Point72 Asset Management Steve Cohen | 2,265,528 | $69,370,467 | -9% | 0.12% |
| 3. | Millennium Management Israel Englander | 1,519,230 | $46,518,823 | +647% | 0.02% |
| 4. | Tang Capital Management Kevin C. Tang | 1,333,639 | $40,836,026 | +1% | 1.57% |
| 5. | Palo Alto Investors William Leland Edwards | 673,520 | $20,623,182 | -18% | 3.82% |