Spyre Therapeutics Inc. (SYRE)

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Institutional Investors' Holdings

Filing Period:

No.	Name	Shares	Value	% Port
1.	Fmr Llc	3,785,877	$79,678,740	0%
2.	Vr Adviser, Llc	2,372,714	$51,060,805	3.5%
3.	Rtw Investments, Llc	2,232,760	$48,048,995	0.75%
4.	Franklin Resources Inc	687,090	$14,786,177	0%
5.	Wellington Management Group Llp	635,455	$13,674,992	0%