The Most Wanted Drug Lords

4. Ismael Zambada-García

While Guzman’s run in the drug world is over for the time being, his partner in crime, nicknamed “El Mayo”, remains the active leader of the Mexican Sinaloa cartel. Although they are famous for their high-quality cocaine, the cartel has become increasingly involved with trafficking of other substances, including methamphetamines, marijuana, and heroin. However, what makes El Mayo so menacing is his quick hand when it comes to making and breaking alliances. The U.S. Department of State offers a reward of $5 million for any information leading to the drug lord’s arrest, making him one of the most wanted candidates today.