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Septerna, Inc. (SEPN): Among The Stocks With At Least $30 Million In Insider Spending Recently

We recently compiled a list of the 10 Stocks With At Least $30 Million In Insider Spending Recently. In this article, we are going to take a look at where Septerna, Inc. (NASDAQ:SEPN) stands against the other stocks. We previously covered 10 stocks with at least $20 million in insider spending recently.

Trump administration’s tariffs on goods imported from Canada and Mexico, as well as additional duties on China, took effect yesterday. As expected, the stock market reacted immediately. The technology index fell 1.2%, hitting its lowest point in almost four months, wiping out post-election gains, while blue-chip companies declined 1.5% or 650 points.

“Tariffs of these magnitude will drive both Canada and Mexico into a recession,” JP Morgan analysts wrote in their daily Tuesday note, writes The Street. Analysts added that higher costs and supply-chain disruptions will affect U.S. growth and domestic stocks. The tariffs could impact $2.2 trillion of global trade and provoke economic slowdowns in the U.S.

Many analysts have downgraded their U.S. stock projections, believing that strong earnings in 2025 may be more challenging. The broader market index is expected to finish the year around 9% higher than in 2024, but that’s still lower than the early January forecast of 12.2%.

The biggest potential positive factor, many experts are banking on, is a productivity boost from AI and expected lower interest rates. Morgan Stanley’s Andrew Slimmon suggests that the adoption of AI could lead to a productivity boom, similar to what happened with the Internet in the late 1990s.

With market fluctuations and uncertainty at play, insider trading draws attention. Executives and insiders, who possess valuable insights into company strategies, plans, and future moves, may engage in trades worth examining. For example, when a CEO or CFO invests their own money in company stock, it can signal strong confidence in the company’s potential.

Insider buying and selling can be influenced by a range of factors, so these actions should be evaluated in the broader context of a company’s financial health, industry trends, and overall market conditions. This underscores the importance of thorough research before making any investment. While insider trading activity can provide useful insights into a company’s potential, it should be considered alongside other key factors to help investors make well-informed decisions.

Today, we’ll focus on stocks with at least $30 million in insider spending. We used Insider Monkey’s stock screener to find stocks where at least one insider purchase in the last five months was worth $30 million or more. While the total value of all insider purchases could be higher, we only looked at those over $30 million. Since more than 10 stocks met these criteria, we chose the top 10 with the largest insider purchases above $30 million.

Our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds, focusing on insider trading and stock picks from hedge fund investor newsletters and conferences. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 373.4% since May 2014, beating its benchmark by 218 percentage points (see more details here).

For each stock, we provide details on the highest individual purchase, the number of insider purchases higher than $30 million over the last three months and the company’s current market capitalization. Let’s take a look at 10 stocks with at least $30 million in insider spending recently.

A biotechnologist in a lab wearing an apron and safety glasses, working on a biopharmaceutical process.

Septerna, Inc. (NASDAQ:SEPN)

Highest Individual Purchase: $68,911,200.00

Number of Purchases Above $30 million: 1

Market Capitalization: $273.521 million

Seventh among 10 stocks with at least $30 million in insider spending recently is Septerna, a clinical-stage biotech. The South San Francisco-headquartered company is engaged in the discovery and development of G protein-coupled receptor oral small molecule product candidates.

Septerna is focused on three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. This is one of the 10 best rebound stocks to invest in now.

On October 28, one insider acquired $68.91 million worth of Septerna, Inc. (NASDAQ:SEPN) shares at a price of $18 per share. Currently, the stock is trading at $6.16 having lost 73.10% since the beginning of the year. The biggest drop in the stock’s price of 57% happened on February 18 after the company announced it would stop the Phase 1 clinical trial of SEP-786. One of its previously leading drug candidates SEP-786 targets a GPCR implicated in hypoparathyroidism. The decision came after two participants in the trial experienced an unexpected increase in bilirubin levels, which is a potential sign of liver issues. The elevated bilirubin levels were reversible, and the company did not find any evidence of serious adverse events in the trial.

For the third quarter of 2024, the company reported revenue of $176,000, which compares to revenue of $33,000 in the same period of 2023. Net loss attributable to common stockholders amounted to $20.52 million, compared to a net loss of $10.95 million in the third quarter of 2023.

Four analysts have an average “Moderate Buy” on Septerna, Inc. (NASDAQ:SEPN) stock, with a price target of $34, according to MarketBeat.

Overall SEPN ranks 7th on our list of the stocks with at least $30 million in insider spending recently. While we acknowledge the potential of SEPN as an investment, our conviction lies in the belief that AI stocks hold greater promise for delivering higher returns, and doing so within a shorter time frame. If you are looking for an AI stock that is more promising than SEPN but that trades at less than 5 times its earnings, check out our report about the cheapest AI stock.

READ NEXT: 20 Best AI Stocks To Buy Now and Complete List of 59 AI Companies Under $2 Billion in Market Cap

Disclosure: None. This article is originally published at Insider Monkey.

AI, Tariffs, Nuclear Power: One Undervalued Stock Connects ALL the Dots (Before It Explodes!)

Artificial intelligence is the greatest investment opportunity of our lifetime. The time to invest in groundbreaking AI is now, and this stock is a steal!

AI is eating the world—and the machines behind it are ravenous.

Each ChatGPT query, each model update, each robotic breakthrough consumes massive amounts of energy. In fact, AI is already pushing global power grids to the brink.

Wall Street is pouring hundreds of billions into artificial intelligence—training smarter chatbots, automating industries, and building the digital future. But there’s one urgent question few are asking:

Where will all of that energy come from?

AI is the most electricity-hungry technology ever invented. Each data center powering large language models like ChatGPT consumes as much energy as a small city. And it’s about to get worse.

Even Sam Altman, the founder of OpenAI, issued a stark warning:

“The future of AI depends on an energy breakthrough.”

Elon Musk was even more blunt:

“AI will run out of electricity by next year.”

As the world chases faster, smarter machines, a hidden crisis is emerging behind the scenes. Power grids are strained. Electricity prices are rising. Utilities are scrambling to expand capacity.

And that’s where the real opportunity lies…

One little-known company—almost entirely overlooked by most AI investors—could be the ultimate backdoor play. It’s not a chipmaker. It’s not a cloud platform. But it might be the most important AI stock in the US owns critical energy infrastructure assets positioned to feed the coming AI energy spike.

As demand from AI data centers explodes, this company is gearing up to profit from the most valuable commodity in the digital age: electricity.

The “Toll Booth” Operator of the AI Energy Boom

  • It owns critical nuclear energy infrastructure assets, positioning it at the heart of America’s next-generation power strategy.
  • It’s one of the only global companies capable of executing large-scale, complex EPC (engineering, procurement, and construction) projects across oil, gas, renewable fuels, and industrial infrastructure.
  • It plays a pivotal role in U.S. LNG exportation—a sector about to explode under President Trump’s renewed “America First” energy doctrine.

Trump has made it clear: Europe and U.S. allies must buy American LNG.

And our company sits in the toll booth—collecting fees on every drop exported.

But that’s not all…

As Trump’s proposed tariffs push American manufacturers to bring their operations back home, this company will be first in line to rebuild, retrofit, and reengineer those facilities.

AI. Energy. Tariffs. Onshoring. This One Company Ties It All Together.

While the world is distracted by flashy AI tickers, a few smart investors are quietly scooping up shares of the one company powering it all from behind the scenes.

AI needs energy. Energy needs infrastructure.

And infrastructure needs a builder with experience, scale, and execution.

This company has its finger in every pie—and Wall Street is just starting to notice.

Wall Street is noticing this company also because it is quietly riding all of these tailwinds—without the sky-high valuation.

While most energy and utility firms are buried under mountains of debt and coughing up hefty interest payments just to appease bondholders…

This company is completely debt-free.

In fact, it’s sitting on a war chest of cash—equal to nearly one-third of its entire market cap.

It also owns a huge equity stake in another red-hot AI play, giving investors indirect exposure to multiple AI growth engines without paying a premium.

And here’s what the smart money has started whispering…

The Hedge Fund Secret That’s Starting to Leak Out

This stock is so off-the-radar, so absurdly undervalued, that some of the most secretive hedge fund managers in the world have begun pitching it at closed-door investment summits.

They’re sharing it quietly, away from the cameras, to rooms full of ultra-wealthy clients.

Why? Because excluding cash and investments, this company is trading at less than 7 times earnings.

And that’s for a business tied to:

  • The AI infrastructure supercycle
  • The onshoring boom driven by Trump-era tariffs
  • A surge in U.S. LNG exports
  • And a unique footprint in nuclear energy—the future of clean, reliable power

You simply won’t find another AI and energy stock this cheap… with this much upside.

This isn’t a hype stock. It’s not riding on hope.

It’s delivering real cash flows, owns critical infrastructure, and holds stakes in other major growth stories.

This is your chance to get in before the rockets take off!

Disruption is the New Name of the Game: Let’s face it, complacency breeds stagnation.

AI is the ultimate disruptor, and it’s shaking the foundations of traditional industries.

The companies that embrace AI will thrive, while the dinosaurs clinging to outdated methods will be left in the dust.

As an investor, you want to be on the side of the winners, and AI is the winning ticket.

The Talent Pool is Overflowing: The world’s brightest minds are flocking to AI.

From computer scientists to mathematicians, the next generation of innovators is pouring its energy into this field.

This influx of talent guarantees a constant stream of groundbreaking ideas and rapid advancements.

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A New Dawn is Coming to U.S. Stocks

I work for one of the largest independent financial publishers in the world – representing over 1 million people in 148 countries.

We’re independently funding today’s broadcast to address something on the mind of every investor in America right now…

Should I put my money in Artificial Intelligence?

Here to answer that for us… and give away his No. 1 free AI recommendation… is 50-year Wall Street titan, Marc Chaikin.

Marc’s been a trader, stockbroker, and analyst. He was the head of the options department at a major brokerage firm and is a sought-after expert for CNBC, Fox Business, Barron’s, and Yahoo! Finance…

But what Marc’s most known for is his award-winning stock-rating system. Which determines whether a stock could shoot sky-high in the next three to six months… or come crashing down.

That’s why Marc’s work appears in every Bloomberg and Reuters terminal on the planet…

And is still used by hundreds of banks, hedge funds, and brokerages to track the billions of dollars flowing in and out of stocks each day.

He’s used this system to survive nine bear markets… create three new indices for the Nasdaq… and even predict the brutal bear market of 2022, 90 days in advance.

Click to continue reading…