Renaissance Technologies Portfolio: 10 Biggest Stocks

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This article looks at the Renaissance Technologies Portfolio: 10 Biggest Stocks.

The American quant hedge fund is known for using statistical and mathematical tools to drive its investment programs. It was founded in 1982 by Jim Simons, a mathematician who worked as a code breaker for the US National Security Agency during the Cold War.

The Renaissance founder stepped down from active hedge fund management in 2010 and resigned as its executive chairman in 2021. Simons passed away in May last year.

The firm is now headed by Peter Brown, who has a strong educational background in mathematics and computer science.

It has been a challenging summer for quant funds, and according to a report in Business Insider, Renaissance Technologies’ two funds that are available to investors, Renaissance Institutional Equities Fund (RIEF) and Renaissance Institutional Diversified Alpha (RIDA), were down 5.1% and 3.9% in July, continuing the decline from June.

The firm’s assets have shrunk in recent years; however, 2024 was a strong year, with RIEF returning 22.7% – its best year since 2011. Despite a tough last couple of months, RIEF and RIDA were up by 5.6% and 6.5%, respectively, during the first seven months of 2025.

With that said, let’s now head over to see the biggest stocks in the Renaissance Technologies Portfolio.

Renaissance Technologies Portfolio: 10 Biggest Stocks

Jim Simons of Renaissance Technologies

Methodology

We scanned Renaissance Technologies’ 13F portfolio as of June 30, 2025. From there, we picked the top 10 stocks according to their stake value and ranked them in ascending order.

Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 373.4% since May 2014, beating its benchmark by 218 percentage points (see more details here).

10. Gilead Sciences, Inc. (NASDAQ:GILD)

Stake Value as of Q2 2025: $628,232,881

Gilead Sciences, Inc. (NASDAQ:GILD) is among the Renaissance Technologies Portfolio: 10 Biggest Stocks. On September 16, JPMorgan analyst Chris Schott lifted the stock’s price target to $145 from $135 while maintaining an Overweight rating for its shares.

While the firm left most of its large-cap biopharma estimates unchanged, it adjusted share price targets on a move from December 2025 to December 2026.

The adjustment reflects a 29% upside potential for Gilead Sciences, Inc. (NASDAQ:GILD) from its closing share price on September 22.

Overall, Wall Street analysts maintain a positive outlook for the stock, with a consensus Buy rating.

Gilead Sciences, Inc. (NASDAQ:GILD) is a biopharmaceutical company engaged in the development of medicines to prevent and treat various life-threatening diseases, including HIV, viral hepatitis, and cancer.

9. Roblox Corporation (NYSE:RBLX)

Stake Value as of Q2 2025: $641,894,527

Roblox Corporation (NYSE:RBLX) is among the Renaissance Technologies Portfolio: 10 Biggest Stocks. On September 22, JPMorgan raised the stock’s price target to $160 from $150, while maintaining an Overweight rating for its shares.

The firm noted an increase in engagement on Roblox Corporation (NYSE:RBLX)’s platform during Q2, driven by Grow a Garden. It expects the momentum to continue in the third quarter due to Steal a Brainrot and 99 Nights in the Forest.

The company’s concurrent users reached 43 million in late August, well above its prior record of 32 million, the analysts told investors in a note. JPMorgan anticipates the encouraging platform engagement to result in a ‘healthy upside’ to the management’s guidance for the third quarter.

Roblox Corporation (NYSE:RBLX) offers an immersive platform for communication and connection, allowing users to create, work, learn, play, and connect in experiences developed by its global community of creators.

The stock has had a stellar 2025, gaining 130% year-to-date as of September 23.

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