Protalix Biotherapeutics Inc. (PLX) Attracts A Huge Investment By A Large Hedge Fund

Highbridge Capital Management disclosed a 5.3% brand new stake in medical research company Protalix Biotherapeutics Inc. (NYSE:PLX). PLX lost a $1.3 million investment by Kevin Kotler’s Broadfin Capital during the third quarter so this new $2 million position by Highbridge Capital is a welcome development. The details of Highbridge’s disclosure can be seen below.

Ownership Summary Table

Name Sole Voting Power Shared Voting Power Sole Dispositive Power Shared Dispositive Power Aggregate Amount Owned Power Percent of Class
Highbridge Capital Management 0 6,523,399 0 6,523,399 6,523,399 5.3%
HIGHBRIDGE CAPITAL MANAGEMENT

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Page 1 of 6 – SEC Filing

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No.   )*

Protalix
BioTherapeutics, Inc.

(Name of Issuer)

Common Stock,
par value $0.001 per share

(Title of Class of Securities)

74365A101

(CUSIP Number)

December
13, 2016

(Date of event which requires filing of this statement)
Check the appropriate box to designate the rule pursuant to which this Schedule 13G is filed:
¨ Rule 13d-1(b)
x Rule 13d-1(c)
¨ Rule 13d-1(d)
(Page 1 of 6 Pages)

______________________________

*The remainder of this cover page shall
be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any
subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder
of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of
1934 (“Act“) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other
provisions of the Act (however, see the Notes)

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Page 2 of 6 – SEC Filing

1

NAMES OF REPORTING PERSONS

Highbridge Capital Management, LLC

2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ¨

(b) ¨

3 SEC USE ONLY
4

CITIZENSHIP OR PLACE OF ORGANIZATION

State of Delaware

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON WITH
5

SOLE VOTING POWER

0

6

SHARED VOTING POWER

6,523,399 shares of Common Stock

7

SOLE DISPOSITIVE POWER

0

8

SHARED DISPOSITIVE POWER

6,523,399 shares of Common Stock

9

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

6,523,399 shares of Common Stock

10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ¨
11

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

5.3%

12

TYPE OF REPORTING PERSON

IA, OO

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Page 3 of 6 – SEC Filing

Item 1(a). NAME OF ISSUER:
The name of the issuer is Protalix BioTherapeutics, Inc. (the “Company“).
Item 1(b). ADDRESS OF ISSUER’S PRINCIPAL EXECUTIVE OFFICES:
The Company’s principal executive offices are located at 2 Snunit Street, Science Park, POB 455, Carmiel 20100, Israel.
Item 2(a). NAME OF PERSON FILING:
Item 2(b). ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:
Item 2(c). CITIZENSHIP:
This statement is filed by:

Highbridge Capital Management, LLC

40 West 57th Street, 32nd Floor

New York, New York 10019

Citizenship: State of Delaware

The foregoing person is hereinafter sometimes referred to as the “Reporting Person.”
Item 2(d). TITLE OF CLASS OF SECURITIES:
Common Stock, par value $0.001 per share (the “Common Stock“).
Item
2(e).
CUSIP NUMBER:
74365A101
Item 3. IF THIS STATEMENT IS FILED PURSUANT TO RULES 13d-1(b) OR 13d-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:
(a) ¨ Broker or dealer registered under Section 15 of the Act,
(b) ¨ Bank as defined in Section 3(a)(6) of the Act,
(c) ¨ Insurance Company as defined in Section 3(a)(19) of the Act,
(d) ¨ Investment Company registered under Section 8 of the Investment Company Act of 1940,
(e) ¨ An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);
(f) ¨ Employee Benefit Plan or Endowment Fund in accordance with Rule 13d-1(b)(1)(ii)(F),
(g) ¨ Parent Holding Company or control person in accordance with Rule 13d-1(b)(1)(ii)(G),

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Page 4 of 6 – SEC Filing

(h) ¨ Savings Association as defined in Section 3(b) of the Federal Deposit Insurance Act,
(i) ¨ A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act;
(j) ¨ A non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J);
(k) ¨ Group, in accordance with Rule 13d-1(b)(1)(ii)(K).

If filing as a non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J),
please

specify
the type of institution: _____________________________________

Item 4. OWNERSHIP.

(a)       Amount
beneficially owned:

As of the date hereof, Highbridge Capital
Management, LLC, as the trading manager of Highbridge International LLC and Highbridge Tactical Credit & Convertibles Master
Fund, L.P. (collectively, the “Highbridge Funds“), may be deemed to be the beneficial owner of 6,523,399 shares
of Common Stock held by the Highbridge Funds.

(b)       Percent
of class:

The percentages used herein and in the
rest of this Schedule 13G are calculated based upon 123,777,137 currently outstanding which is the sum of (i) 99,930,402 shares
of Common Stock outstanding as of November 1, 2016, as reported in the Company’s Quarterly Report on Form 10-Q for the quarterly
period ended September 30, 2016 filed with the Securities and Exchange Commission on November 9, 2016 and (ii) 23,846,735 shares
of Common Stock issued by the Company in the exchange transaction described in the Current Report on Form 8-K filed by the Company
with the Securities and Exchange Commission on December 7, 2016. Therefore, as of the date hereof, Highbridge Capital Management,
LLC may be deemed to beneficially own approximately 5.3% of the outstanding shares of Common Stock of the Company.

The foregoing should not be construed in
and of itself as an admission by the Reporting Person as to beneficial ownership of the shares of Common Stock held by the Highbridge
Funds.

Item 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.
Not applicable.
Item 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.
See Item 4.

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Page 5 of 6 – SEC Filing

Item 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.
Not applicable.
Item 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.
Not applicable.
Item 9. NOTICE OF DISSOLUTION OF GROUP.
Not applicable.
Item 10. CERTIFICATION.
The Reporting Person hereby makes the following certification:
By signing below the Reporting Person certifies that, to the best of its knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

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Page 6 of 6 – SEC Filing

SIGNATURES

After reasonable
inquiry and to the best of our knowledge and belief, the undersigned certifies that the information set forth in this statement
is true, complete and correct.

DATED: December 23, 2016

HIGHBRIDGE CAPITAL MANAGEMENT, LLC

By: /s/ John Oliva

Name: John Oliva

Title: Managing Director

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