ProQR Therapeutics N.V. (PRQR): Jennison Associates Grabbed A Large Chunk Of This Biotech Stock

Page 3 of 5 – SEC Filing

Item 3 If this statement is filed pursuant to Rules 13d-1(b),

or 13d-2(b), or (c) check whether the person filing is a:

(a) ( ) Broker or Dealer registered under Section 15 of the Act

(b) ( ) Bank as defined in Section 3(a) (6) of the Act

(c) ( ) Insurance Company as defined in Section 3(a) (19) of

the Act

(d) ( ) Investment Company registered under Section 8 of the

Investment Company Act

(e) (X) Investment Adviser in accordance with Section

240.13d-1(b) (1) (ii) (E)

(f) ( ) Employee Benefit Plan, Pension Fund which is subject

to the provision of the Employee Retirement Income Security

Act of 1974 or Endowment Fund in accordance with Section

240.13d-1(b) (ii) (F)

(g) ( ) Parent Holding Company or control person, in accordance

with Section 240.13(b) (ii) (G)

(h) ( ) A savings association as defined by Section 3(b) of the

Federal Deposit Insurance Act

(i)( ) A church plan that is excluded from the definition of an

investment company under Section 3(c) (4) of the Investment Company

Act of 1940.

(j)( ) Group, in accordance with Section 240.13d-1(b) (1) (ii) (J).

If this statement is filed pursuant to Section 240.13d-1(c), check

this box. ( )

Item 4 Ownership:

Provide the following information regarding the aggregate number

and percentage of the class of securities of the issuer identified

in Item 1.

(a) Amount Beneficially Owned: 2,674,844

(b) Percent of Class: 11.5%

(c) Number of shares as to which the person has:

(i) sole power to vote or to direct the vote: 2,674,844

(ii) shared power to vote or to direct the vote: 0

(iii) sole power to dispose or to direct the disposition of: 0

(iv) shared power to dispose or to direct the disposition of: 2,674,844

Jennison Associates LLC (“Jennison”) furnishes

investment advice to several investment companies,

insurance separate accounts, and institutional clients (“Managed

Portfolios”). As a result of its role as investment adviser of

the Managed Portfolios, Jennison may be deemed to be the

beneficial owner of the shares of the Issuer’s Common Stock

held by such Managed Portfolios. Prudential Financial, Inc.

(“Prudential”) indirectly owns 100% of equity interests of

Jennison. As a result, Prudential may be deemed to have the

power to exercise or to direct the exercise of such voting

and/or dispositive power that Jennison may have with respect to

the Issuer’s Common Stock held by the Managed Portfolios.

Jennison does not file jointly with Prudential, as such, shares

of the Issuer’s Common Stock reported on Jennison’s 13G may be

included in the shares reported on the 13G filed by Prudential.

These shares were acquired in the ordinary course of business,

and not with the purpose or effect of changing or influencing

control of the Issuer. The filing of this statement should not

be construed as an admission that Jennison is, for the purposes

of Sections 13 or 16 of the Securities Exchange Act of 1934,

the beneficial owner of these shares.

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