Dear Valued Visitor,

We have noticed that you are using an ad blocker software.

Although advertisements on the web pages may degrade your experience, our business certainly depends on them and we can only keep providing you high-quality research based articles as long as we can display ads on our pages.

To view this article, you can disable your ad blocker and refresh this page or simply login.

We only allow registered users to use ad blockers. You can sign up for free by clicking here or you can login if you are already a member.

Pfizer Inc. (PFE) Teams Up With NIH NCI CCR On Immunotherapy

Pfizer Inc. (NYSE:PFE) has recently entered into a Cooperative Research and Development Agreement (CRADA) with the National Institutes of Health (NIH) National Cancer Institute (NCI) to work with the latter’s Center for Cancer Research (CCR) on clinical development programs evaluating three investigational immunotherapy agents: 1) PF-04518600, which targets OX40 (CD134); 2) utomilumab or PF-05082566, which targets 4-1BB (CD137); and 3) avelumab or PF-06834635 or MSB0010718C, which is a fully human anti-PD-L1 lgG1 monoclonal antibody.

Pfizer PFE pharmaceutical stock

pio3 /

Clinical Development Program

Jeffrey Schlom, Ph.D., CCR Chief of the Laboratory of Tumor Immunology and Biology, James Gulley, Ph.D., CCR Chief of the Genitourinary Malignancies Branch, and Chris Boshoff, Pfizer Global Product Development Senior Vice President (SVP) and Head of Immuno-oncology, Translational, and Early Development, will co-lead the entire clinical development program.

The three investigational immunotherapy agents will be evaluated as monotherapies, in combination with one another, and in combination with standard therapies such as chemotherapy, radiation therapy, among others across different types of cancer.

“The CRADA is an important collaboration for us as we seek to realize the full potential of immunotherapy and hope to ultimately transform the cancer treatment paradigm,” elaborated Boshoff.

Prospective Randomized Evaluation of Celecoxib Integrated Safety vs. Ibuprofen or Naproxen (PRECISION) Clinical Trial Results

In other news, Pfizer Inc. (NYSE:PFE) has recently presented at the American Heart Association (AHA) annual meeting the results of the PRECISION clinical trial.

The results have shown that patients with osteoarthritis (OA) or rheumatoid arthritis (RA) administered with prescription doses of Celebrex (celecoxib), ibuprofen, and naproxen are at similar rates of risk for cardiovascular (CV) disease. Consequently, it addresses the notion that Celebrex is associated with higher CV risks.

The results have also demonstrated that patients treated with Celebrex are at lower risk fot gastrointestinal symptoms than patients treated with ibuprofen or naproxen.

To control OA or RA symptoms, the patients need to be regularly treated with non-steroidal anti-inflammatory drugs (NSAIDs).

The company will publish further clinical trial results soon. Pfizer funded the long-term PRECISION clinical trial designed in 2005, which had enrolled more than 24,000 subjects.

On Monday, Pfizer Inc. (NYSE:PFE) closed at $32.38.

Follow Pfizer Inc (NYSE:PFE)
Trade (NYSE:PFE) Now!

Note: This article is written by Adam Russell and was originally published at Market Exclusive.

DOWNLOAD FREE REPORT: Warren Buffett's Best Stock Picks

Let Warren Buffett, George Soros, Steve Cohen, and Daniel Loeb WORK FOR YOU.

If you want to beat the low cost index funds by 19 percentage points per year, look no further than our monthly newsletter.In this free report you can find an in-depth analysis of the performance of Warren Buffett's entire historical stock picks. We uncovered Warren Buffett's Best Stock Picks and a way to for Buffett to improve his returns by more than 4 percentage points per year.

Bonus Biotech Stock Pick: You can also find a detailed bonus biotech stock pick that we expect to return more than 50% within 12 months.
Subscribe me to Insider Monkey's Free Daily Newsletter
This is a FREE report from Insider Monkey. Credit Card is NOT required.