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Personalis, Inc. (PSNL) ctDNA Test Predicts TNBC Relapse Risk Post-Therapy

Personalis, Inc. (NASDAQ:PSNL) has unveiled breakthrough clinical data showing its NeXT Personal ctDNA blood test can accurately identify triple negative breast cancer (TNBC) patients at high risk of relapse following neoadjuvant therapy (NAT).

Results from the PREDICT DNA and SCANDARE studies, presented at ASCO 2025, reveal that patients with detectable circulating tumor DNA (ctDNA) after NAT are up to 10 times more likely to experience recurrence than those who test negative.

A laboratory technician using high tech equipment to sequence cancer genomics.

Notably, ctDNA detection post-NAT proved a stronger predictor of relapse than traditional pathology, and patients who cleared ctDNA, even with residual disease, had excellent outcomes. Nearly half of post-NAT ctDNA detections were below 100 parts per million, underscoring the assay’s ultrasensitive performance.

A second study from Institut Curie confirmed that post-NAT ctDNA status is highly prognostic, with ctDNA-positive patients facing a 36-fold higher risk of distant relapse. Experts say these findings highlight the clinical need for ultrasensitive molecular residual disease (MRD) testing and could pave the way for ctDNA-guided decisions on additional therapy in early TNBC. Personalis, Inc. (NASDAQ:PSNL) aims to use this data to seek reimbursement coverage and optimize care for breast cancer patients.

Personalis, Inc. (NASDAQ:PSNL) is revolutionizing cancer care with cutting-edge personalized testing that supports active management throughout the patient journey. Using highly sensitive assays that profile both tumor and normal tissue alongside proprietary algorithms, they provide deep insights into cancer’s progression. Their solutions enable early detection of minimal residual disease (MRD) and recurrence, guide the selection of targeted therapies through comprehensive genomic profiling, and improve biomarker strategies for drug development. Personalis is headquartered in Fremont, California.

While we acknowledge the potential of PSNL to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than PSNL and that has 100x upside potential, check out our report about this cheapest AI stock.

READ NEXT: 10 Best Cancer Stocks to Invest in for Long-Term Gains and 10 Most Oversold Stocks to Buy According to Billionaires.

Disclosure: None.

The $250 Trillion AI Hype is Real. A few years from now, you’ll probably wish you’d bought this stock.

Dr. Inan Dogan

Dr. Ian Dogan

Co-Founder and Research Director at Insider Monkey

When Jeff Bezos said that one breakthrough technology would shape Amazon’s destiny, even Wall Street’s biggest analysts were caught off guard.

Fast forward a year and Amazon’s new CEO Andy Jassy described generative AI as a “once-in-a-lifetime” technology that is already being used across Amazon to reinvent customer experiences.

At the 8th Future Investment Initiative conference, Elon Musk predicted that by 2040 there would be at least 10 billion humanoid robots, with each priced between $20,000 and $25,000.

Do the math. According to Musk, this technology could be worth $250 trillion by 2040.

Put another way, that’s roughly equal to:

  • 175 Teslas
  • 107 Amazons
  • 140 Metas
  • 84 Googles
  • 65 Microsofts
  • And 55 Nvidias

And here’s the wild part — this $250 trillion wave isn’t tied to one company, but to an entire ecosystem of AI innovators set to reshape the global economy.

It’s a leap so massive, it could reshape how businesses, governments, and consumers operate worldwide.

Even if that $250 trillion figure sounds ambitious, major firms like PwC and McKinsey still see AI unlocking multi-trillion-dollar potential.

How could anything be worth that much?

The answer lies in a breakthrough so powerful it’s redefining how humanity works, learns, and creates.

And this breakthrough has already set off a frenzy among hedge funds and Wall Street’s top investors.

What most investors don’t realize is that one under-owned company holds the key to this $250 trillion revolution.

In fact, Verge argues this company’s supercheap AI technology should concern rivals.

Before I reveal the details, let’s talk about how some of the richest people on the planet are positioning themselves.

  • Bill Gates sees artificial intelligence as the “biggest technological advance in my lifetime,” more transformative than the internet or personal computer, capable of improving healthcare, education, and addressing climate change.
  • Larry Ellison — through Oracle, is spending billions on Nvidia chips and partnering with Cohere to embed generative AI across Oracle’s cloud and apps.
  • Warren Buffett — not known for tech hype — says this breakthrough could have a ‘hugely beneficial social impact.

When billionaires from Silicon Valley to Wall Street line up behind the same idea — you know it’s worth paying attention to.

Even as we admire what Tesla, Nvidia, Alphabet, and Microsoft have built, we believe an even greater opportunity lies elsewhere…

But the real story isn’t Nvidia — it’s a much smaller company quietly improving the critical technology that makes this entire revolution possible.

And judging by what I’m hearing from both Silicon Valley insiders and Wall Street veterans…

This prediction might not be bold at all:

A few years from now, you’ll wish you’d owned this stock.

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Dr. Inan Dogan

Dr. Ian Dogan

Co-Founder and Research Director at Insider Monkey

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