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ISIS Pharmaceuticals, Inc. (ISIS) Scores Another Big Biotech Deal With Biogen Idec Inc. (BIIB)

Make that four collaborations between Biogen Idec Inc. (NASDAQ:BIIB) and ISIS Pharmaceuticals, Inc. (NASDAQ:ISIS) in the last two years. The pair announced a six-year deal Monday to develop antisense technology for novel therapies treating neurological diseases. This is an excellent development for investors in both companies because each gets to leverage an area of strength — the technology platform for Isis and an understanding of neurological diseases for Biogen — to advance future revenue potential. It also helps bring awareness to similar technology platforms in the industry.

Biogen Idec Inc (NASDAQ:BIIB)

A match made in biotech heaven

ISIS Pharmaceuticals, Inc. (NASDAQ:ISIS) will capture a $100 million upfront payment in the third quarter and additional milestone payments worth up to $220 million, not including cost reimbursements related to clinical trials. Meanwhile, Biogen Idec Inc. (NASDAQ:BIIB) expands its push into validated antisense gene therapy technology. What the heck is antisense technology? Essentially, Isis can develop small molecule and biologic drugs to silence or activate genes that play key roles in genetic diseases. It is fixing the body’s ailments at the most basic genetic level.

The takeaway for investors is that it has big potential for treating the underlying causes of neurological diseases — not just the symptoms — which is precisely why Biogen Idec Inc. (NASDAQ:BIIB) tapped the technology. It wasn’t the company’s first rodeo, however. The same platform was the center of the three previous collaborations targeting various hereditary muscular and neurological diseases. It may finally be time for RNA-based therapies and gene therapies to hit the prime time, which could have profound implications for the biotech industry.

Silence is golden

Rather than look at ISIS Pharmaceuticals, Inc. (NASDAQ:ISIS) in an isolated bubble, it may be more productive to consider what the development means for similar or even competing technologies. For instance, earlier this year Isis and Sanofi (Genzyme) gained approval for the antisense drug Kynamro developed to treat homozygous familial hypercholesterolaemia, or HoFH. It is a rare genetic disease that reduces the body’s ability to remove LDL cholesterol.

Fellow biotech Aegerion Pharmaceuticals, Inc. (NASDAQ:AEGR) has developed its own drug for HoFH called Juxtapid. While the next-generation drug is not in the same class as ISIS Pharmaceuticals, Inc. (NASDAQ:ISIS)’, it does have the major advantage of being administered orally, versus once-weekly injections for Kynamro. JPMorgan analyst Cory Kasimov estimates peak sales in the United States and Europe to hit $500 billion — a respectable watermark for a rare disease. The ability to compete directly with Isis could make Aegerion Pharmaceuticals, Inc. (NASDAQ:AEGR) a respectable takeover target given its sub-$3 billion market cap.

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