Dear Valued Visitor,

We have noticed that you are using an ad blocker software.

Although advertisements on the web pages may degrade your experience, our business certainly depends on them and we can only keep providing you high-quality research based articles as long as we can display ads on our pages.

To view this article, you can disable your ad blocker and refresh this page or simply login.

We only allow registered users to use ad blockers. You can sign up for free by clicking here or you can login if you are already a member.

Is Arrowhead Pharmaceuticals Inc (ARWR)’s Recently Published U.S. Patent Application A Blockbuster?

– U.S. Patent and Trademark Office publishes Arrowhead’s latest patent application on αvβ6 integrin ligands.

– αvβ6 integrin ligands enable high affinity extrahepatic delivery of RNAi trigger sequences to multiple tissues.

– Arrowhead cornering the market on its patent pending extrahepatic compositions for targeting αvβ6 integrin ligands.

– The company that is able to move RNAi outside of the liver will create a ton of value.

Arrowhead Pharmaceuticals Inc (NASDAQ: ARWR) business model of going after extrahepatic targets and establishing first mover advantage has the potential to be amplified by gaining patent protection for an extrahepatic targeting ligand composition. Arrowhead’s patent application is looking to exclude, or require a license with, others in targeting a number of different tissues outside of the liver for the life of a patent (around 17 years).

Arrowhead indicated at its last Analyst Day meeting in New York on October 16, 2018 that since there will be more RNAi competitors going after liver targets, it believes that targeting indications outside of the liver will be more productive in building a long-term valuable company.

10 Pharmacist Shortage Countries in Need of Pharmacists in 2017

wavebreakmedia/Shutterstock.com

RNAi drugs from the three main RNAi companies: Arrowhead Pharmaceuticals Inc (NASDAQ: ARWR), Alnylam Pharmaceuticals (NASDAQ: ALNY), and Dicerna Pharmaceuticals (NASDAQ: DRNA) currently target the liver. They are able to target the liver by conjugating a high-affinity targeting ligand to an RNAi trigger sequence. This targeting ligand acts like a magnet by being able to bind itself to receptors found on the liver. The result is specific delivery of an RNAi drug directly within the liver.

The process is quick and efficient and has shown to provide incredible results, as once the trigger sequence is delivered to the liver, its biological effects of knocking down specific genes can last for over 3 months, but its plasma half-life is such that the drug gets eliminated from the bloodstream within approximately 24 hours. This is a big win for the present state of RNAi platforms with regards to safety, as most safety issues arise while the drug remains in the bloodstream.

Identifying an effective targeting ligand to get an RNAi drug to a specific tissue is a major challenge. The well-known method of targeting the liver is by using a synthetic triantennary N-acetylgalactosamine (GalNAc) ligand. The GalNAc is designed to bind with high affinity and specificity to the asialoglycoprotein receptor (ASGPR) found in the liver. In short, the GalNAc ligand has become a very effective tool in delivering an RNAi trigger sequence to the liver.

The GalNAc structure itself, however, is not proprietary, therefore any RNAi company is free to use it by conjugating it to its own proprietary RNAi trigger sequence. The conjugation of the GalNAc ligand to an RNAi trigger sequence can be done via a variety of means, including both proprietary and non-proprietary structures. The GalNAc is currently actively being used by a number of RNAi companies, including competing RNAi drugs that are designed to treat HBV and Alpha-1 antitrypsin deficiency.

Identifying extrahepatic targeting ligands to target other tissues outside of the liver is the next big challenge RNAi companies are facing. Arrowhead has been working hard in being able to advance its RNAi TRiM™ platform to the next level by going extrahepatic. The Company is currently guiding on the delivery of two new extrahepatic drugs in the clinic, ARO-HIF2 (2019) for the treatment of clear cell renal cell carcinoma (ccRCC), and ARO-ENaC (1H2020) for the treatment of cystic fibrosis.

Follow Arrowhead Pharmaceuticals Inc. (NASDAQ:ARWR)
Trade (NASDAQ:ARWR) Now!
(Click here if you experience problems viewing an html code instead of the widget)

DOWNLOAD FREE REPORT: Warren Buffett's Best Stock Picks

Let Warren Buffett, George Soros, Steve Cohen, and Daniel Loeb WORK FOR YOU.

If you want to beat the low cost index funds by 19 percentage points per year, look no further than our monthly newsletter.In this free report you can find an in-depth analysis of the performance of Warren Buffett's entire historical stock picks. We uncovered Warren Buffett's Best Stock Picks and a way to for Buffett to improve his returns by more than 4 percentage points per year.

Bonus Biotech Stock Pick: You can also find a detailed bonus biotech stock pick that we expect to return more than 50% within 12 months.
Subscribe me to Insider Monkey's Free Daily Newsletter
This is a FREE report from Insider Monkey. Credit Card is NOT required.
Loading...