Ignyta Inc. (RXDX): Great Point Partners Reports New Stake

In a recent 13G filing with the US SECJeffrey Jay and David Kroin‘s Great Point Partners reported the acquisition of 2.05 million shares of  Ignyta Inc. (NASDAQ:RXDX), which account for 4.94% percent of the total amount of shares, and represent a new addition to the Great Point Partners’ portfolio. Investors usually file Schedule 13G or 13D when their ownership exceeds 5% of class and in its latest filing, Great Point added that on April 29, its ownership was above 5%, but due to the exercise of an underwriter’s option to purchase shares, the stake accounted for less than 5% of Ignyta’s common stock.

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Ignyta is a biotechnology company that works on developing new therapies for the patients suffering from various types of cancer. Since the beginning of the year, Ignyta’s stock has lost 34.47%. The company is scheduled to release its earnings later today, after the market closes, and it is estimated that it will report a loss per share of $0.83 for the quarter.

At the end of December, Ignyta (NASDAQ:RXDX) was in 15 hedge fund portfolios from our database, versus 12 hedge funds in a previous quarter. Kevin Kotler’s Broadfin Capital reported the biggest position in Ignyta (NASDAQ:RXDX), valued at $30.2 million, and Joseph Edelman’s Perceptive Advisors held the second biggest position, worth around $24.3 million. Other investors long the stock are Israel Englander’s Millennium Management, Steven Boyd’s Armistice Capital and Alan Frazier’s Frazier Healthcare Partners,  Michael S. Weiss and Lindsay A. Rosenwald’s Opus Point Partners Management, David Lamond’s Lamond Capital Partners and Steve Cohen’s Point72 Asset Management.

You can access the original SEC filing by clicking here.

Ownership Summary Table

Name Sole Voting Power Shared Voting Power Sole Dispositive Power Shared Dispositive Power Aggregate Amount Owned Power Percent of Class
Great Point Partners 0 2,050,000 0 2,050,000 2,050,000 4.94%
Dr. Jeffrey R. Jay, M.D 0 2,050,000 0 2,050,000 2,050,000 4.94%
Mr. David Kroin 0 2,050,000 0 2,050,000 2,050,000 4.94%

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Page 1 of 10 – SEC Filing

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

 

Schedule 13G

 

Under the Securities Exchange Act of
1934

(Amendment No.    )*

Ignyta, Inc.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

451731103

(CUSIP Number)

April 29, 2016

(Date of Event which Requires Filing of this
Statement)

Check the appropriate box to designate the rule
pursuant to which this Schedule is filed:

o Rule 13d-1(b)
x Rule 13d-1(c)
o Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

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Page 2 of 10 – SEC Filing

CUSIP No. 451731103 13G Page 2 of 9 Pages
1. NAMES OF REPORTING PERSONS
Great Point Partners, LLC
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
37-1475292
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) o
(b) o
3. SEC USE ONLY
4. CITIZENSHIP OR PLACE OF ORGANIZATION
USA
NUMBER OF SHARES

BENEFICIALLY


OWNED BY EACH

REPORTING PERSON

WITH
5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

 

2,050,000

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

 

2,050,000

9.

AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

2,050,000

   
10.

CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(See Instructions)

o

     
11.

PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

4.94%1

   
12.

TYPE
OF REPORTING PERSON
(See Instructions)

IA

1 Based on a total of 41,539,081 shares outstanding, as reported by the Issuer on a 424(b)(5) prospectus filed
with the SEC on April 29, 2016, after giving effect to the exercise in full of an underwriter’s option to purchase 1,200,000
shares, as reported by the Issuer in a press release on May 2, 2016.

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Page 3 of 10 – SEC Filing

CUSIP No. 451731103 13G Page 3 of 9 Pages
1. NAMES OF REPORTING PERSONS
Dr. Jeffrey R. Jay, M.D.
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) o
(b) o
3. SEC USE ONLY
4. CITIZENSHIP OR PLACE OF ORGANIZATION
USA
NUMBER OF SHARES

BENEFICIALLY

OWNED BY EACH

REPORTING PERSON

WITH
5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

2,050,000

 

7.

SOLE DISPOSITIVE POWER

 

0

8.

SHARED DISPOSITIVE POWER

 

2,050,000

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

2,050,000

10.

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES
(See Instructions)

o
11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

4.94%1

12.

TYPE OF REPORTING PERSON (See Instructions)

IN

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Page 4 of 10 – SEC Filing

CUSIP No. 451731103 13G Page 4 of 9 Pages
1. NAMES OF REPORTING PERSONS
Mr. David Kroin
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) o
(b) o
3. SEC USE ONLY
4. CITIZENSHIP OR PLACE OF ORGANIZATION
USA
NUMBER OF SHARES

BENEFICIALLY

OWNED BY EACH

REPORTING PERSON

WITH
5.

SOLE
VOTING POWER

 

0

6.

SHARED
VOTING POWER

 

2,050,000

 

7.

SOLE
DISPOSITIVE POWER

0

8.

SHARED
DISPOSITIVE POWER

2,050,000

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

2,050,000

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) o
11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

4.94%1

12.

TYPE OF REPORTING PERSON (See Instructions)

IN

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Page 5 of 10 – SEC Filing

CUSIP No. 451731103 13G Page 5 of 9 Pages

Explanatory Note: This Schedule 13G is being filed to report
that on April 29, 2016, the reporting persons’ beneficial ownership exceeded 5%. Subsequently, as a result of the
exercise of an underwriter’s option to purchase shares of the issuer’s common stock, such beneficial ownership
has decreased to below 5%.

Item 1.
(a) Name of Issuer
Ignyta, Inc.
(b) Address of Issuer’s Principal Executive Offices
11111 Flintkote Avenue, San Diego, CA 92121
Item 2.
(a) Name of Person Filing
Great Point Partners, LLC
Dr. Jeffrey R. Jay, M.D.
Mr. David Kroin
The Reporting Persons have entered into a Joint Filing Agreement, dated May 9, 2016, a copy of which is filed with this Schedule 13G as Exhibit A, pursuant to which the Reporting Persons have agreed to file this statement jointly in accordance with the provisions of Rule 13d-1(k)(1) under the Act.
(b) Address of Principal Business Office, or if none, Residence
The address of the principal business office of each of the
Reporting Persons is
165 Mason Street, 3rd Floor
Greenwich, CT 06830
(c) Citizenship
Great Point Partners, LLC is a limited liability company organized under the laws of the State of Delaware. Dr. Jeffrey R. Jay, M.D. is a citizen of the United States. Mr. David Kroin is a citizen of the United States.
(d) Title of Class of Securities
Common Stock
(e) CUSIP Number
451731103
Item 3. If this statement is filed pursuant to §240.13d-1(b) or 240.13d.2(b) or (c), check whether the person
filing is a:
Not Applicable.
(a) o Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o)
(b) o Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).
(c) o Insurance company as defined in Section 3(a)(19) of the Act (15. U.S.C. 78c).
(d) o

Investment Company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).

(e) o

An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E).

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Page 6 of 10 – SEC Filing

CUSIP No. 451731103 13G Page 6 of 9 Pages
(f) o An employee benefit plan or endowment fund in accordance
with §240.13d-1(b)(1)(ii)(F).
(g) o A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G).
(h) o A savings associations as defined in Section 3(b) of the Federal Deposit
Insurance Act (12 U.S.C. 1813).
(i) o A church plan that is excluded from the definition of an investment company
under Section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3).
(j) o Group, in accordance with §240.13d-1(b)(1)(ii)(J).
Item 4. Ownership
Biomedical Value Fund, L.P. (“BVF”) is the record owner of 548,346 shares (the “BVF Shares”). Great Point Partners, LLC (“Great Point”) is the investment manager of BVF, and by virtue of such status may be deemed to be the beneficial owner of the BVF Shares. Each of Dr. Jeffrey R. Jay, M.D. (“Dr. Jay”), as senior managing member of Great Point, and Mr. David Kroin (“Mr. Kroin”), as special managing member of Great Point, has voting and investment power with respect to the BVF Shares, and therefore may be deemed to be the beneficial owner of the BVF Shares.
Biomedical Institutional Value Fund, L.P. (“BIVF”) is the record owner of 56,724 shares (the “BIVF Shares”). Great Point is the investment manager of BIVF, and by virtue of such status may be deemed to be the beneficial owner of the BIVF Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the BIVF Shares, and therefore may be deemed to be the beneficial owner of the BIVF Shares.
Biomedical Offshore Value Fund, Ltd. (“BOVF”) is the record owner of 623,979 shares (the “BOVF Shares”). Great Point is the investment manager of BOVF, and by virtue of such status may be deemed to be the beneficial owner of the BOVF Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the BOVF Shares, and therefore may be deemed to be the beneficial owner of the BOVF Shares.
GEF-SMA, L.P. (“GEF-SMA”) is the record owner of 661,797 shares (the “GEF-SMA Shares”). Great Point is the investment manager with respect to the GEF-SMA, and by virtue of such status may be deemed to be the beneficial owner of the GEF-SMA Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the GEF-SMA Shares, and therefore may be deemed to be the beneficial owner of the GEF-SMA Shares.
Class D Series of GEF-PS, LP (“GEF-PS”) is the record owners of 159,154 shares (the “GEF-PS Shares”). Great Point is the investment manager with respect to the GEF-PS, and by virtue of such status may be deemed to be the beneficial owner of the GEF-PS Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the GEF-PS Shares, and therefore may be deemed to be the beneficial owner of the GEF-PS Shares.
Notwithstanding the above, Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Shares, the BIVF Shares, the BOVF Shares, the GEF-SMA Shares and the GEF-PS Shares, except to the extent of their respective pecuniary interests.

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Page 7 of 10 – SEC Filing

CUSIP No. 451731103 13G Page 7 of 9 Pages
Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified
in Item 1.
1. Great Point Partners, LLC
(a) Amount beneficially owned: 2,050,000
(b) Percent of class:  4.94%2
(c) Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote: – 0 –
(ii) Shared power to vote or to direct the vote: 2,050,000
(iii) Sole power to dispose or to direct the disposition of: – 0 -.
(iv) Shared power to dispose or to direct the disposition of: 2,050,000
2. Dr. Jeffrey R. Jay, M.D.
(a) Amount beneficially owned: 2,050,000
(b)

Percent of class: 4.94%2

(c)

Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: 0.
(ii) Shared power to vote or to direct the vote: 2,050,000
(iii) Sole power to dispose or to direct the disposition of: 0.
(iv) Shared power to dispose or to direct the disposition of: 2,050,000
3. Mr. David Kroin
(a) Amount beneficially owned: 2,050,000
(b) Percent of class: 4.94%2
(c) Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote: 0.
(ii) Shared power to vote or to direct the vote: 2,050,000
(iii) Sole power to dispose or to direct the disposition of: 0.
(iv) Shared power to dispose or to direct the disposition of: 2,050,000
Item 5. Ownership of Five Percent or Less of a Class
2 Based on a total of 41,539,081 shares outstanding, as reported by the Issuer on a 424(b)(5) prospectus filed with the SEC on April 29, 2016, after giving effect to the exercise in full of an underwriter’s option to purchase 1,200,000, as reported by the Issuer in a press release on May 2, 2016.

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Page 8 of 10 – SEC Filing

CUSIP No. 451731103 13G Page 8 of 9 Pages

If this statement is
being filed to report the fact that as of the date hereof each of the Reporting Persons has ceased to be the beneficial owner of
more than five percent of the class of securities, check the following x.

Item 6. Ownership of More than Five Percent on Behalf of Another Person:
See Item 4.
Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding
Company
Not Applicable.
Item 8. Identification and Classification of Members of the Group
Not Applicable.
Item 9. Notice of Dissolution of Group
Not Applicable.
Item 10. Certification
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above
were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer
of the securities and were not acquired and are not held in connection with or as participant in any transaction having that
purpose or effect.

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Page 9 of 10 – SEC Filing

CUSIP No. 451731103 13G Page 9 of 9 Pages

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and correct.

Date: May 9, 2016

GREAT POINT PARTNERS, LLC
By: /s/ Dr. Jeffrey R. Jay, M.D.
Dr. Jeffrey R. Jay, M.D.,
   as senior managing member
/s/ Dr. Jeffrey R. Jay,
M.D.
DR. JEFFREY R. JAY, M.D.
/s/ Mr. David Kroin
MR. DAVID KROIN

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Page 10 of 10 – SEC Filing

Exhibit
A

 

AGREEMENT REGARDING THE JOINT FILING OF
SCHEDULE 13G

The undersigned hereby agree as follows:

(i)        Each of them is
individually eligible to use the Schedule 13G to which this Exhibit is attached, and such Schedule 13G is filed on behalf of each
of them; and

(ii)       Each of them is responsible for the timely filing of such Schedule 13G and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information is inaccurate.

Date: May 9, 2016

 

GREAT POINT PARTNERS, LLC
By: /s/ Dr. Jeffrey R. Jay, M.D.
Dr. Jeffrey R. Jay, M.D.,
   as senior managing member
/s/ Dr. Jeffrey R. Jay, M.D.
DR. JEFFREY R. JAY, M.D.
/s/ Mr. David Kroin
MR. DAVID KROIN

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