Dear Valued Visitor,

We have noticed that you are using an ad blocker software.

Although advertisements on the web pages may degrade your experience, our business certainly depends on them and we can only keep providing you high-quality research based articles as long as we can display ads on our pages.

To view this article, you can disable your ad blocker and refresh this page or simply login.

We only allow registered users to use ad blockers. You can sign up for free by clicking here or you can login if you are already a member.

Curis, Inc. (CRIS), Bristol Myers Squibb Co. (BMY), Novartis AG (ADR) (NVS): Can Stopping This Hedgehog Create New Cancer Treatments?

Curis, Inc. (NASDAQ:CRIS) and Roche Holding Ltd. (ADR) (OTCMKTS:RHHBY) Genentech unit have stopped a hedgehog — not a spiky little beast, but a signaling pathway that could be the key in developing next-generation network-targeted cancer therapies. The hedgehog signaling pathway transmits information to embryonic cells that help them properly develop, and the proteins that move along these pathways regulate cell growth, differentiation, and survival.

However, if the pathway is improperly activated, it can cause a variety of cancers, most notably basal cell carcinoma, a common type of skin cancer. BCC is not usually fatal, but it can cause disfigurement and tissue destruction. In the United States, 30% of Caucasians are at risk of developing BCC, with 80% of cases occurring on the head and the neck.

Bristol Myers Squibb Co. (NYSE:BMY)

Stopping the hedgehog generates strong sales growth
Curis, Inc. (NASDAQ:CRIS) and Roche Holding Ltd. (ADR) (OTCMKTS:RHHBY)’s hedgehog pathway inhibitor program’s greatest accomplishment, Erivedge, is an orally administered small molecule hedgehog pathway inhibitor. It attempts to interrupt the hedgehog pathway signal within the cells, disrupting the growth of advanced BCC. Erivedge was approved in January 2012, becoming the second skin cancer drug to be approved by the Food and Drug Administration following the approval of Roche Holding Ltd. (ADR) (OTCMKTS:RHHBY)’s melanoma treatment Zelboraf in August 2011. Erivedge also gained Australian approval in May and a conditional EU approval in June.

During clinical trials, Erivedge had a 43% success rate at shrinking BCC for locally advanced patients (when BCC grows deeper into the skin), and a 30% success rate at shrinking BCC for metastatic patients (when BCC spreads to other parts of the body). The treatment costs $7,500 per month for an average treatment period of 10 months.

Last quarter, higher sales of Erivedge fueled Curis, Inc. (NASDAQ:CRIS)’ 24% year-on-year increase in revenue to $5.4 million, as its adjusted EPS loss narrowed from $0.04 to $0.02 per share. Those figures exceeded the consensus estimate for revenue of $4.43 million and a loss of $0.05.

Other hedgehogs are crawling through the pipeline
Although inhibiting the hedgehog signaling pathway is a new approach to treating BCC, other competitors are already emerging. Novartis AG (ADR) (NYSE:NVS)‘s LDE-225 is the most noteworthy one, a hedgehog pathway inhibitor that is currently in clinical trials for treating BCC. It is also currently recruiting participants to test LDE-225 against Temodar for the treatment of brain cancer. LDE-225 is also undergoing preclinical studies in possibly inhibiting the growth of prostate cancer stem cells.

DOWNLOAD FREE REPORT: Warren Buffett's Best Stock Picks

Let Warren Buffett, George Soros, Steve Cohen, and Daniel Loeb WORK FOR YOU.

If you want to beat the low cost index funds by 19 percentage points per year, look no further than our monthly newsletter.In this free report you can find an in-depth analysis of the performance of Warren Buffett's entire historical stock picks. We uncovered Warren Buffett's Best Stock Picks and a way to for Buffett to improve his returns by more than 4 percentage points per year.

Bonus Biotech Stock Pick: You can also find a detailed bonus biotech stock pick that we expect to return more than 50% within 12 months.
Subscribe me to Insider Monkey's Free Daily Newsletter
This is a FREE report from Insider Monkey. Credit Card is NOT required.