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Celgene Corporation (CELG)’s Fading Star

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Drugs can be like the stars. Some shine brightly. Some appear seemingly out of nowhere. And some grow dimmer over time and eventually disappear from the night sky.

Celgene Corporation (NASDAQ:CELG) has plenty of stars in its product portfolio. Revlimid currently stands as the brightest of the bunch. Abraxane and Vidaza are getting brighter. We looked at all three of these drugs previously in The Motley Fool’s series on Celgene’s products and pipeline. In this article we review Thalomid — Celgene’s fading star.

Celgene Corporation (NASDAQ:CELG)A star is born
Thalomid, then known as Thalidomide, was first developed in 1954. It was considered a “wonder drug” in Europe back in the 50s, with uses ranging from insomnia to morning sickness. However, the luster wore off within a few years as doctors noticed incidents of birth defects in children of women who had taken the drug.

Although the drug was banned in many countries by the early 1960s, another usage for Thalidomide was found. A professor in Israel discovered that the drug helped patients with erythema nodosum leprosum, or ENL,  a condition associated with leprosy. While Thalidomide was used for decades for treating the disease, the drug wasn’t officially sanctioned in the U.S. for ENL until Celgene obtained FDA approval in 1998 with the brand name of Synovir.

Synovir was also being used as an experimental treatment of cachexia, a serious weight loss condition suffered by AIDS patients. By the late 1990s, Celgene began exploring other indications for the drug, particularly various forms of cancer. It also began using the brand name of Thalomid. The company ultimately gained FDA approval for Thalomid as a treatment of multiple myeloma in 2004.

Slow fade
After 40 years of being used for many different indications, Thalomid began to shine as an alternative for patients with this blood cancer. However, the shine didn’t burn brightly for long.

Source: Company 10-K reports and 2012 earnings release.

Thalomid peaked in 2008 with around $500 million in sales, but began a steady decline in the following years. The good news for Celgene was that this decrease came about largely due to its own efforts with Revlimid. Thalomid itself contributed in a way to its own undermining. Revlimid is an analog of Thalomid, which means that it has a similar chemical structure but with different properties.

Despite the steady fall in sales, Thalomid still ranks as Celgene’s fourth-highest revenue generator. That standing won’t last too much longer, though, as the company introduces new products and as other drugs like Abraxane begin to really take off.

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