In this article we discuss Billionaire Steve Cohen’s 10 Large-Cap Stock Picks With Huge Upside Potential.

What does the future hold for the US economy and equities amid punitive tariffs, immigration crackdown and federal spending cuts? That’s the million-dollar question as the chairman and CEO of hedge fund Point72 Asset Management, Steve Cohen, sounds alarm bells warning the US economy could be on the brink amid macroeconomic uncertainties.

The billionaire investor has fired a warning shots, insisting that President Donald Trump’s aggressive trade policy could cause the economy to grow at a much slower rate of 1.5% in the second half of the year, down from an initial growth forecast of 2.5%. The warning comes on Trump touting tariffs for various purposes, including lowering trade imbalances and gaining more negotiating power over other nations. Nevertheless, their negative impact continues as the service sector, a key economic driver, grows slowly from 2023.

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“Tariffs cannot be positive, okay? I mean, it’s a tax,” Cohen said Friday at the FII Priority Summit in Miami Beach, Florida. “On top of that, we have slowing immigration, which means the labor force will not grow as rapidly as … the last five years and so.”

Cohen has warned that the good times that saw the equity market trickle to record highs are over as the US economy’s outlook is uncertain due to the tariff plan laid out by Trump. True to Cohen’s warnings, the US stock market has pulled back significantly from record highs. Given the uncertain macro environment, the S&P 500 is already down by about 8% for the year and on the cusp of entering the correcting phase.

Echoing similar sentiments is Morgan Stanley CIO Mike Wilson, who insists a significant correction has been on the cards since 2023. According to Wilson, investors had pushed stocks upwards, with valuation skyrocketing above historical norms and beyond the value of their fundamentals. Therefore, a rapid descent should be expected as headwinds soar left, right and centre.

“I’m actually pretty negative for the first time in a while,” Cohen said. “It may only last a year or so, but it’s definitely a period where I think the best gains have been had and wouldn’t surprise me to see a significant correction.”

On the other hand, Cohen remains optimistic about the artificial intelligence outlook despite DeepSeek’s revelation and development on the development of cost-effective AI models rattling the US markets. According to Cohen, DeepSeek’s development of cost-effective AI models is positive despite raising concerns about spending on powerful AI chips developed by US companies.

Cohen is one of the billionaire investors taking advantage of the artificial intelligence boom through strategic investments. His portfolio at Point72 Asset Management hedge boasts significant exposure to tech giants developing and leveraging various AI innovations. Likewise, Point72 Asset Management has already unveiled a new artificial intelligence-focused fund that posted a 14% gain in the last three months of 2024 growing to $1.5 billion.

Our Methodology

We combed Point 72 SEC Q4 2024 13F filings to identify billionaire Steve Cohen’s 10 large-cap stock picks with huge upside potential. We focused on stocks with a market cap of more than $40 billion with significant upside potential. We then analyzed the stocks on why they stand out as solid investments well poised to generate significant value even on the overall equity market turning bearish. Finally, we listed the stocks in ascending order of upside potential.

Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 373.4% since May 2014, beating its benchmark by 218 percentage points (see more details here).

Billionaire Steve Cohen’s 10 Large-Cap Stock Picks With Huge Upside Potential

10. Microsoft Corporation (NASDAQ:MSFT)

Market Cap as of April 24: $2.78 Trillion

Point72 Asset Management’s Equity Stake: $713.79 Million

Analysts’ Upside Potential as of April 24: 32%

Number of Hedge Fund Holders: 317

Microsoft Corporation (NASDAQ:MSFT) is a multinational technology company that develops and supports a wide range of software, services, devices, and solutions. It also operates in cloud computing, online search, and other online services. While the stock has pulled back significantly on the artificial intelligence-driven run fizzling, Mizuho analyst Gregg Moskowitz believes the company is well-positioned to deliver impressive growth over the long term.

The analyst has a $475 price target on the stock based on the expectation that Microsoft’s cloud unit, Azure, will benefit from public/hybrid cloud migration and digital transformation of complex workflows. Companies and governments widely use the cloud-powered version of Office Microsoft 365, further strengthening the tech giant’s revenue base.

Accordingly, Moskowitz believes Microsoft Corporation (NASDAQ:MSFT) has made significant progress in generative artificial intelligence, as shown by its $14 billion investment in OpenAI and other AI solutions. Azure AI revenue was up by 157% year-over-year in fiscal Q2 2025, accounting for 13% of all Azure revenues. According to the analyst, Wall Street is also underestimating the company’s long-term revenue growth outlook. Microsoft is on course to spend $80 billion on AI data centre infrastructure and chips in 2025 as it looks to capitalize on the AI boom.

9. UnitedHealth Group Incorporated (NYSE:UNH)

Market Cap as of April 24: $389.54 Billion

Point72 Asset Management’s Equity Stake: $190.62 Million

Analysts’ Upside Potential as of April 24: 33.60%

Number of Hedge Fund Holders: 150

UnitedHealth Group Incorporated (NYSE:UNH) is a healthcare company that specializes in health insurance and healthcare services. It offers consumer-oriented health benefit plans and services for national and public sector employers. The company remains under pressure to slash the annual profit forecast, citing higher-than-expected medical costs in the Medicare plan.

UnitedHealth Group Incorporated (NYSE:UNH) already feels the brunt of lower government payments and soaring medical costs. Medical costs are rising as more seniors return to hospitals for procedures they postponed during the pandemic. Consequently, it is forcing companies like UnitedHealth Group to incur more costs. For its first quarter of 2025, UnitedHealth Group reported an adjusted income of $7.20 a share, missing analysts’ estimates of $7.29.

UnitedHealth Group Incorporated (NYSE:UNH) also cut its full-year earnings guidance to between $26 and $26.50 a share from a previous guidance of between $29.50 and $30. Revenue in the quarter was up $9.8 billion year over year to $109.6 billion. TD Cowen has already cut its stock price target to $520 from $609 while maintaining a Buy rating, concerned by rising medical costs that are eating into margins.