In this article, we will look at the Billionaire Steve Cohen’s 10 Large-Cap Stock Picks with Highest Upside Potential.
Steve Cohen is one of the most revered names on Wall Street, running one of the biggest hedge funds. Point 72 Asset Management is one of the most closely tracked hedge funds, with a diversified equity portfolio worth more than $80 billion in assets under management. With more than 3,000 holdings, the active portfolio has no single investment accounting for more than 2.2%.
Point 72 Management’s diversified portfolio was the catalyst behind a 17.5% gain in 2025, in line with the 17.9% gain for the S&P 500. After an impressive run, Steve Cohen is creating an executive committee to help him lead the hedge fund’s strategy and direction amid heightened market volatility. Whereas the billionaire investor will retain the roles of chairman and Chief Executive Officer, he will cede the title of President to Harry Schwefel.
In explaining these organizational changes, Cohen stated, “Over the past few years our firm has grown across virtually every metric — AUM, headcount, global footprint. As we continue to pursue the growth of existing and new strategies, I want to ensure our management structure matches our current scale and growth ambitions.”
The change seeks to ensure that the management structure aligns with the firm’s current scale and growth ambitions. While Cohen has not traded for the firm for almost two years, he remains closely involved, overseeing investments and mentoring traders.
Cohen’s investment portfolio is heavily weighted toward technology stocks, which account for about 28% of the portfolio, followed by financial and healthcare holdings. As the volatile market took a toll on many funds in March amid the escalation of the Iran war, Cohen advised Point72 traders on how to navigate the turmoil.
Point72 lost 0.7% in March, even as other funds fell more, and the tech-heavy Nasdaq 100 shed nearly 10%. The hedge fund has since bounced back and recouped all its losses, bringing its total returns for the year to 7.5%, against a 4% gain for the S&P 500 over the same period.
Amid the impressive run, let’s take a look at some of Steve Cohen’s large-cap stock picks with the highest upside potential.
Steven Cohen of Point72 Asset Management
Our Methodology
To compile the list of Steve Cohen’s 10 Large-Cap Stock Picks with Highest Upside Potential, we reviewed the latest 13F filings of Point72 Asset Management. From the portfolio, we focused on stocks with a market cap of more than $10 billion. We further trimmed the list by selecting stocks with upside potential of more than 20% (as of May 13) and also detailed the number of hedge funds holding stakes in them in Q4 2025. Finally, we ranked the stocks in ascending order based on Point72 Asset Management’s equity stakes in them.
Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research shows we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 498.7% since May 2014, beating its benchmark by 303 percentage points (see more details here).
Billionaire Steve Cohen’s Large-Cap Stock Picks with Highest Upside Potential
10. Thermo Fisher Scientific Inc. (NYSE:TMO)
Stock Upside Potential: 36.97%
Market Capitalization: $173.16 Billion
Point 72 Asset Management Equity Stakes: $253.14 Million
Number of Hedge Fund Holders: 113
Thermo Fisher Scientific Inc. (NYSE:TMO) is one of billionaire Steve Cohen’s large-cap stock picks with the highest upside potential. On April 28, Thermo Fisher Scientific Inc. (NYSE:TMO) opened a new Bioprocess Design Center.
The new center in Plainville, Massachusetts, is designed to bring life-changing therapies to patients. In addition, customers will be able to partner with the company’s experts to address complex bioprocessing challenges. The center features 4,000 square feet of laboratory and training space where customers can access comprehensive bio-production solutions and expert scientists and engineers.
The opening of the Bioprocess Design Center is a significant milestone as Thermo Fisher Scientific seeks to enhance drug development. That’s in part because the center will help customers unlock productivity gains, reduce risks as they scale, and shorten timelines. The center is also positioned to strengthen connections and collaborations across the country by creating more opportunities to share innovation.
Thermo Fisher Scientific Inc. (NYSE:TMO) is a global leader serving science, providing high-end analytical instruments, laboratory equipment, software, services, consumables, and chemicals. It enables customers in pharmaceutical/biotech, healthcare, academia, and government to accelerate life sciences research, solve complex analytical challenges, and improve patient diagnostics.
9. DoorDash, Inc. (NASDAQ:DASH)
Stock Upside Potential: 56.82%
Market Capitalization: $67.73 Billion
Point 72 Asset Management Equity Stakes: $279.05 Million
Number of Hedge Fund Holders: 91
DoorDash, Inc. (NASDAQ:DASH) is one of billionaire Steve Cohen’s large-cap stock picks with the highest upside potential. On May 8, analysts at DA Davidson reiterated a Neutral rating on DoorDash Inc. (NASDAQ:DASH) and lowered the price target to $200 from $224.
The research firm trimmed its price target to reflect broader compression in internet marketplace multiples. Amid the price target cut, it has reiterated resilient consumer demand that was the catalyst behind solid first-quarter earnings and guidance.
Continued product improvements and healthy consumer demand trends drove a 27% increase in orders in the first quarter to 933 million. Consequently, revenue increased 33% year over year to $4 billion as adjusted EBITDA increased 28% to $754 million.
On the other hand, analysts at Citizens have reiterated a Market Outperform rating on DoorDash and a $250 price target, based on 24 times the stock’s 2027 EBITDA estimate. The research firm remains optimistic about the company’s prospects as payments represent a significant opportunity and a competitive advantage.
DoorDash, Inc. (NASDAQ:DASH) is a leading technology company and logistics platform that connects customers with local businesses, providing on-demand delivery of food, groceries, alcohol, and retail items. Its three-sided marketplace matches consumers with merchants and independent courier drivers (“Dashers”) through its app and website.
8. Capital One Financial Corporation (NYSE:COF)
Stock Upside Potential: 37.63%
Market Capitalization: $115.48 Billion
Point 72 Asset Management Equity Stakes: $290.07 Million
Number of Hedge Fund Holders: 136
Capital One Financial Corporation (NYSE:COF) is one of billionaire Steve Cohen’s large-cap stock picks with the highest upside potential. On May 9, Capital One Financial Corp (NYSE:COF) board of directors approved a $0.80 a share quarterly dividend.
The dividend is to be paid on June 1, 2026, to shareholders of record as of May 19, 2026. It also translates to an annualized dividend of $3.2 a share and a dividend yield of 1.7%. The quarterly dividend comes on the heels of Capital One Financial delivering solid first-quarter 2026 results. Net Income came in at $2.2 billion, or $3.34 a share, compared to $2.1 billion, or $3.26 a share, in Q4 2025. Revenue in the quarter totaled $15.2 billion, down 2% sequentially.
First-quarter results underscored solid top-line growth and strong credit performance. Additionally, Capital One Financial continues to benefit from the integration of the Discover acquisition, which is driving growth momentum.
Capital One Financial Corporation (NYSE:COF) is a diversified financial services holding company that offers a broad array of financial products and services, primarily focused on credit cards, banking, and auto loans for consumers, small businesses, and commercial clients.
7. Autodesk, Inc. (NASDAQ:ADSK)
Stock Upside Potential: 37.81%
Market Capitalization: $52.21 Billion
Point 72 Asset Management Equity Stakes: $311.44 Million
Number of Hedge Fund Holders: 81
Autodesk, Inc. (NASDAQ:ADSK) is one of billionaire Steve Cohen’s large-cap stock picks with the highest upside potential. On May 4, Autodesk introduced Autodesk for Small Business, a program designed to help freelancers, small teams, and growing firms in the Design and Make industries. With more than one‑third of professionals now working independently, Autodesk aims to provide tools that match the way small businesses operate, especially since 80% of owners say they struggle to balance running their business with doing the actual work.
The initiative focuses on three areas. First, Experience: a new Small Business Hub on Autodesk.com offers a simplified way to explore products, compare options, and share feedback. Product updates across AutoCAD, Revit, Fusion, and Flow Studio improve speed, reduce errors, and introduce AI‑powered features like text‑to‑command modeling and generative 3D. Second, Flexibility: later this year, customers will be able to buy fewer Flex tokens, lowering upfront costs and allowing teams to scale usage as projects demand. Third, Special Offers: Autodesk is rolling out discounts and free certification vouchers to help more small businesses access its technology.
A new State of Small Business report shows solopreneurs and micro firms in Design and Make grew nearly 10% in 2025, outpacing the broader small business economy. Autodesk’s launch reflects this momentum, positioning the company as a partner for independent professionals shaping the future of design, construction, and media.
Earlier, Oppenheimer analysts reiterated an Outperform rating on Autodesk, with a $325 price target. The bullish stance aligns with growing confidence in the company’s competitive advantages in artificial intelligence, including its ability to leverage vast proprietary data and deep end-market context to develop smarter design solutions.
The company also possesses significant intellectual property in AI technologies. According to the research firm, these advantages, along with critical data safeguards, are difficult for startups to replicate.
Autodesk, Inc. (NASDAQ:ADSK) is a global leader in 3D design, engineering, and entertainment software, providing tools that allow professionals to design, simulate, and build projects digitally. Their software is used extensively in architecture, construction, manufacturing, and media to automate workflows, optimize designs with AI, and manage project lifecycles.
6. Atlassian Corporation (NASDAQ:TEAM)
Stock Upside Potential: 63.07%
Market Capitalization: $24.72 Billion
Point 72 Asset Management Equity Stakes: $313.53 Million
Number of Hedge Fund Holders: 57
Atlassian Corporation (NASDAQ:TEAM) is one of billionaire Steve Cohen’s large-cap stock picks with the highest upside potential. On May 7, Piper Sandler reiterated an Overweight rating on Atlassian Corporation (NASDAQ:TEAM) and a $175 price target.
The research firm remains optimistic about the company’s outlook following the annual user conference and investor forum. In the conference, management addressed some of the concerns that have contributed to about a 45% decline in shares. In addition, Piper Sandler has touted the company’s subscription annual recurring growth that has accelerated over the past two years.
The Research firm has also touted the company’s move to open its Teamwork Graph so that agents from across the ecosystem can search and reason securely across tools and teams. Consequently, it provides context for agentic AI to scale in the enterprise.
Earlier, analysts at BTIG reiterated a Buy rating on Atlassian Corporation but cut the price target to $110 from $140. The research firm remains bullish while expecting the company to deliver solid cloud revenue growth amid an expanded partnership with Google Cloud. The partnership paves the way for integrating AI models with the Rovo AI platform and Google Workspace.
Atlassian Corporation (NASDAQ:TEAM) provides collaboration, productivity, and workflow software designed for software developers, IT professionals, and business teams. Its core products are used to plan work, manage IT services, automate tasks using AI (Rovo), and connect teams.
While we acknowledge the potential of TEAM to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than TEAM and that has 100x upside potential, check out our report about the cheapest AI stock.
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