In this article, we discuss Two Sigma’s 10 Stock Picks with Huge Upside Potential.

Two Sigma Advisors is one of the leading players in the quantitative hedge fund space, according to Archive Market Research’s analysis. The quant fund operates as an investment management company and was founded in 2001 by David Siegel, a computer scientist, and John Overdeck, a mathematician. The fund manages $60 billion worth of assets as of April 2025.

Quant funds and their multi-strategy counterparts often do well in the market. A Reuters analysis found that many quant hedge funds posted double-digit growth in 2024. This growth happened despite “negative drivers” in sectors like energy, metals, and European equities. Two Sigma, alongside quant funds like D.E. Shaw and Citadel, also managed solid performance last year.

The hedge fund’s Spectrum Fund returned 10.9% and 14.3% for the Absolute Return Enhanced Fund. But one might argue that for a hedge fund that relies on complex algorithms to make investment decisions, the asset manager should have beat the market. For context, the S&P 500 finished 2024 with a total gain of 25.0%.

READ ALSO: Billionaire Ray Dalio’s Bridgewater’s 10 Stock Picks with Huge Upside Potential and Billionaire Mario Gabelli’s 10 Large-Cap Stock Picks with Huge Upside Potential.

In August last year, the billionaire founders of the hedge fund exited from active management because they couldn’t resolve tension between them.

“Over the past year and a half, we and our senior management team have dedicated significant effort to securing the long-term success and stability of Two Sigma. Throughout this process, our own roles have been a central consideration. Today, we are confident that stepping back from our day-to-day management roles is the right decision at this time,” the co-founders said in a letter to investors.

But recent reports indicate that Overdeck is returning to active management. “John has determined now is the right time for him to return to this role in order to progress certain priorities and decisions he believes are important to the future of Two Sigma,” Two Sigma said in a letter. Siegel chose to remain outside of the fund’s top ranks but had “full confidence” in Scott Hoffman, one of the Co-CEOs who took over last year.

It is good news that Two Sigma won’t be held back by feuding management because they need it to navigate a challenging market. According to a Reuters analysis, the risk of recession is alarming, even though it may not be as clear-cut. The report quoted Zurich Insurance Group’s chief market strategist, Guy Miller, who said that the risk of a US recession is quite plausible. “Recession risks have risen markedly even if there are some deals struck on tariffs. The risk of a U.S. recession is 50-50, it’s that close.”

Our Methodology

We sifted through Two Sigma Advisors’ SEC Q4 2024 13F filings to create this list. We primarily targeted the fund’s most valuable equity holdings (excluding ETFs and options) and then ranked the picks based on analyst price targets as of May 8, 2025. We picked stocks with an upside potential of at least 30% and then selected the top 10. We have also added the broader hedge fund sentiment for the stocks, as of Q4 2024.

Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 373.4% since May 2014, beating its benchmark by 218 percentage points (see more details here).

Billionaire Quants’ Two Sigma’s 10 Stock Picks with Huge Upside Potential

10. BILL Holdings, Inc. (NYSE:BILL)

Two Sigma Advisors Stake Value: $$94,239,875

Upside Potential as of May 8: 31.19%

Number of Hedge Fund Holders: 64

BILL Holdings, Inc. (NYSE:BILL) is a financial operations platform for small and midsize businesses (SMBs). The company provides a suite of software solutions (BILL Platform, Divvy, Invoice2go, and BILL Pay) that help SMBs manage their accounts payable, accounts receivable, expense management, and other financial workflows through a single integrated platform.

In Q2 fiscal 2025, BILL Holdings, Inc.’s (NYSE:BILL) total revenue increased 14% year-over-year to $362.6 million. Core revenue, which consists of subscription and transaction fees, grew even faster at 16% year-over-year to reach $319.6 million. The company’s customer base expanded to 481,300 businesses as of the quarter end, processing $84 billion in total payment volume, up 13% from the previous year.

In late April 2025, the company revealed that Xero, a global small business platform, would leverage BILL Holdings, Inc.’s (NYSE:BILL) technology to launch US online bill payments. This integration allows SMBs to pay bills without leaving the Xero platform. The integration addresses a critical need as Xero’s research found that 38% of SMBs struggle with tracking due dates and 20% cite difficulties managing and paying bills in one place.

On April 30, 2025, KeyBanc adjusted its price target for BILL Holdings, Inc. (NYSE:BILL) to $60 from $70 while maintaining an Overweight rating. The firm cited “modestly softer spend” anticipated in the second half of 2025.

9. Alphabet Inc. (NASDAQ:GOOGL)

Two Sigma Advisors Stake Value: $747,015,660

Upside Potential as of May 8: 31.32%

Number of Hedge Fund Holders: 234

Alphabet Inc. (NASDAQ:GOOGL) is the parent company of Google, the world’s dominant search engine. The technology conglomerate also owns YouTube, Android operating system, Google Cloud, and a portfolio of other services, including Gmail, Google Maps, and Chrome browser, as well as emerging artificial intelligence (AI) technologies like Gemini.

In its Q1 2025 financial results, Alphabet Inc.’s (NASDAQ:GOOGL) consolidated revenues rose by 12% year-over-year to $90.2 billion. The company reported the most substantial growth in Google Cloud, which surged 28% to reach $12.3 billion. Google Services, including Search, YouTube, and subscriptions, grew by 10% to $77.3 billion. And the company’s net income jumped 46% compared to the same period last year.

Despite these strong financials, Alphabet Inc. (NASDAQ:GOOGL) faces significant headwinds. On May 7, 2025, the company’s shares fell sharply following testimony by Apple’s (NASDAQ:AAPL) SVP of Services Eddy Cue in the Department of Justice’s antitrust lawsuit remedies hearing against Google’s Search business. The testimony suggested that Apple (NASDAQ:AAPL) is “actively looking at” revamping its Safari web browser to focus on AI-powered search engines. The Financial Times, and investors at large, understood this to mean that Apple might end the longtime partnership with Google, which is estimated to be worth $20 billion annually.

Despite this situation, Stifel analysts have maintained their Buy rating and $200.00 price target on Alphabet Inc. (NASDAQ:GOOGL) stock. They cited the company’s excellent financial health with a “GREAT” overall score and robust revenue growth of approximately 13% over the last twelve months.