Alexion Pharmaceuticals, Inc. (ALXN), Pharmacyclics, Inc. (PCYC), Aegerion Pharmaceuticals, Inc. (AEGR), Raptor Pharmaceutical Corp. (RPTP): Have These Four Biotechs Peaked?

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Biotechnology stocks often trade with excessive valuations, until one day, large losses occur. The best way to protect yourself is to be logical when investing, and use industrywide valuing metrics as a way to find limits or exit points. With that said, after massive gains, is it possible that upside for these four top biotech stocks is now limited at best?

Understanding valuation
There’s a big difference between biotechnology and drug companies. For drug companies, most have many products, and all produce revenue. According to NYU, there were 223 companies in this space. In biotechnology, most companies are in the clinical space, and some produce revenue while others do not. Nonetheless, the valuing metrics are different, based on future sales, with the goal being to become a well-established drug company.

The difference in valuation is wide between these two industries, as the drug industry trades at 2.9 times sales while biotechnology is at six times sales. Typically, with companies in biotech either having greater growth or no sales, valuations are higher relative to fundamentals. Therefore, six times “current” sales becomes a healthy valuation while 2.9 times peak sales shows that all upside is priced into a stock.

With that in mind, let’s look at a few companies using this model that may be presenting very little future upside for current shareholders.

“If” peak sales are reached
Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN)‘ Soliris is used to treat rare genetic disorders and diseases. It is currently FDA approved to treat two diseases, but is being developed to treat five additional genetic disorders. Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN) does have four other clinical products, but all are in the early phases of development and are many years from an FDA approval.

Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN)

Soliris could earn peak revenue of $3.5 billion globally if all five additional indications are FDA approved. However, that is a big “if.”

With current 12-month sales of $1.32 billion and top-line growth of 35%, $3.5 billion looks to be a long ways off. In addition, Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN) with a $22 billion market cap trades at a whopping 6.3 times peak sales, more than double the average for peak sales. Therefore, it’s hard to imagine a scenario where Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN) trades significantly higher from this point forward.

Global sales are well accounted for
Pharmacyclics, Inc. (NASDAQ:PCYC) has traded higher by an incredible 6,500% in the last five years, behind the excitement, expectations, and soon-to-be-approved leukemia/lymphoma drug ibrutinib.

Pharmacyclics, Inc. (NASDAQ:PCYC) has partnered with Johnson & Johnson for the development of this drug, sharing 50% of the revenue but only responsible for 40% of the costs. The most recent of estimates, from Goldman, have pegged peak global sales at $6 billion for ibrutinib, which is if all indications are approved and full penetration into the market is met.

If so, Pharmacyclics, Inc. (NASDAQ:PCYC) is poised to earn $3 billion in annual sales by 2025. Currently, the stock is trading with a market cap of $8.7 billion, or exactly 2.9 times the most generous of estimates.

While Pharmacyclics, Inc. (NASDAQ:PCYC) does have two other late-stage products, it appears as though most upside for its blockbuster drug ibrutinib has been valued into its stock, leaving little upside over the next few years.

A questionable future creates risk
Aegerion Pharmaceuticals, Inc. (NASDAQ:AEGR) has rallied 530% over the last year in response to its newly approved drug Juxtapid, which treats a rare-cholesterol disease.

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